Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EGFL7 contributors: mct/pgu - updated : 09-11-2013
HGNC name EGF-like-domain, multiple 7
HGNC id 20594
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • an EMI domain domain at the N-terminus (domain present in a number of extracellular-matrix-associated proteins involved in regulating cell-adhesion)
  • two EGF-like domains and a leucine and valine-rich C-terminal region
    • HOMOLOGY
    interspecies homolog to murine Egfl7 (78.7pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a specific role in regulating vascular tubulogenesis
  • secreted factor implicated in cellular responses such as cell migration and blood vessel formation
  • acting as an antagonist of Notch signalling and affecting neural stem cell renewal
  • may protect endothelial cell from hyperoxia-induced apoptosis by inhibition of mitochondria-dependent apoptosis pathway
  • chemoattractant for endothelial cells, and its expression is restricted to endothelial cells
  • potentially regulates angiogenesis by an autocrine mechanism involving vasculature alone
  • its expression in tumors promotes tumor progression by reducing the expression of endothelial molecules that mediate immune cell infiltration
  • its function in blood vessel development is mediated, at least in part, through modulation of NOTCH signaling
  • role for EGFL7 in developmental and postnatal angiogenesis
  • extracellular matrix-associated protein expressed in activated endothelium
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS development
    text blood vessel development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • binding transmembrane receptors of the Notch Family
  • CASZ1 is required to directly regulate an EGFL7/RhoA-mediated pathway to promote vertebrate vascular development
  • transcriptional pathway involving activation of EGFL7 gene by the transcription factor CASTOR (CASZ1) is required for blood vessel assembly and lumen morphogenesis
    • cell & other
    REGULATION
    activated by hypoxia that upregulates human coronary artery endothelial cells expression of EGFL7 and EGFL7 inhibits expression of intercellular adhesion molecule 1 subsequent to Hypoxia/reoxygenation (H/R) injury
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly upregulated in human epithelial tumor tissues
    tumoral     --over  
    expression is significantly higher in invasive ductal than in invasive lobular breast carcinoma
    constitutional     --low  
    with ACVRL1 showed lower expression in early-onset pre-eclampsia versus late-onset pre-eclampsia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for human epithelial tumors, especially hepatocellular carcinoma and breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
    ANIMAL & CELL MODELS