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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CHFR

contributors: mct - updated : 25-01-2015

HGNC name	checkpoint with forkhead and ring finger domains
HGNC id	20455

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         3 of 8 human cancer cell lines examined did not contain CHFR mRNA tumoral     --low   by aberrant methylation associated with gene silencing in primary hepatocellular carcinomas, oral squamous cell carcinomas , gastric cancer , and ovarian cancer constitutional     --low   led to disorganized multipolar mitotic spindles

Susceptibility

Variant & Polymorphism

Candidate gene	molecular marker to estimate the malignancy of hepatocellular carcinoma
Marker
Therapy target
	System Type Disorder Pubmed cancer     CHFR-mediated downregulation of HLTF may help protect against cancer

ANIMAL & CELL MODELS