| 1 | CHFR, GRB14
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| Insulin-induced cell division is controlled by the adaptor Grb14 in a Chfr-dependent manner.
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| Perdereau D, Cailliau K, Browaeys-Poly E, Lescuyer A, Carré N, Benhamed F, Goenaga D, Burnol AF.
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| Cell Signal 27(4):798-806. doi: 10.1016/j.cellsig.2015.01.003.
2015
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| 2 | CHFR, PBK, PTEN
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| TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
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| Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S.
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| Cell Signal 25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3.
2013
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| 3 | CHFR
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| CHFR is negatively regulated by SUMOylation-mediated ubiquitylation.
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| Bae SJ, Kwon YE, Kim M, Seol JH.
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| Biochem Biophys Res Commun 433(2):194-9. doi: 10.1016/j.bbrc.2013.02.080. Epub 2013 Feb 27.
2013
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| 4 | CHFR
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| CHFR is important for the first wave of ubiquitination at DNA damage sites.
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| Liu C, Wu J, Paudyal SC, You Z, Yu X.
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| Nucleic Acids Res 41(3):1698-710. doi: 10.1093/nar/gks1278. Epub 2012 Dec 24.
2013
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| 5 | CHFR
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| SUMOylation negatively regulates the stability of CHFR tumor suppressor.
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| Kwon YE, Bae SJ, Kim M, Seol JH.
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| Biochem Biophys Res Commun 430(1):213-7. doi: 10.1016/j.bbrc.2012.10.111. Epub 2012 Nov 3.
2013
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| 6 | CHFR, LRP1
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| Aggregated low-density lipoprotein induces LRP1 stabilization through E3 ubiquitin ligase CHFR downregulation in human vascular smooth muscle cells.
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| Cal R, García-Arguinzonis M, Revuelta-López E, Castellano J, Padró T, Badimon L, Llorente-Cortés V.
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| Arterioscler Thromb Vasc Biol 33(2):369-77. doi: 10.1161/ATVBAHA.112.300748. Epub 2012 Dec 13.
2013
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| 7 | CHFR, SMARCA4, SMARCB1, SMARCC1, SMARCD1
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| SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.
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| Jung I, Sohn DH, Choi J, Kim JM, Jeon S, Seol JH, Seong RH.
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| Biochem Biophys Res Commun 418(3):512-7. doi: 10.1016/j.bbrc.2012.01.057. Epub 2012 Jan 20.
2012
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| 8 | CHFR, PARP1
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| CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.
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| Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, Suzuki H, Toyota M, Ariga H, Sasaki Y, Tokino T.
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| J Biol Chem 287(16):12975-84. doi: 10.1074/jbc.M111.321828. Epub 2012 Feb 15.
2012
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| 9 | CHFR
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| CHFR: a key checkpoint component implicated in a wide range of cancers.
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| Sanbhnani S, Yeong FM.
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| Cell Mol Life Sci 69(10):1669-87. doi: 10.1007/s00018-011-0892-2. Epub 2011 Dec 13. Review.
2012
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| 10 | CHFR, MAD2L1
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| CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.
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| Keller JA, Petty EM.
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| Biochem Biophys Res Commun 409(3):389-93. Epub 2011 May 7.
2011
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| 11 | CHFR, PLK1, RNF8
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| Plk1 is negatively regulated by RNF8.
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| Yoshioka T, Kimura M, Saio M, Era S, Okano Y.
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| Biochem Biophys Res Commun 410(1):57-61. Epub 2011 May 24.
2011
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| 12 | CHFR, RNF8
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| Chfr and RNF8 synergistically regulate ATM activation.
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| Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X.
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| Nat Struct Mol Biol 18(7):761-8. doi: 10.1038/nsmb.2078.
2011
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| 13 | CHFR, HLTF
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| CHFR functions as a ubiquitin ligase for HLTF to regulate its stability and functions.
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| Kim JM, Cho EN, Kwon YE, Bae SJ, Kim M, Seol JH.
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| Biochem Biophys Res Commun 395(4):515-20. Epub 2010 Apr 11.
2010
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| 14 | CHFR, KIF22
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| Functional interaction between Chfr and Kif22 controls genomic stability.
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| Maddika S, Sy SM, Chen J.
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| J Biol Chem 284(19):12998-3003. Epub 2009 Mar 25.
2009
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| 15 | CHFR
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| CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB.
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| Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T.
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| Oncogene 28(29):2643-53. Epub 2009 May 18.
2009
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| 16 | CHFR
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| Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.
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| Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N.
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| Int J Cancer 124(11):2607-15.
2009
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| 17 | CHFR
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| Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas.
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| Baba S, Hara A, Kato K, Long NK, Hatano Y, Kimura M, Okano Y, Yamada Y, Shibata T.
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| Oncol Rep 22(5):1173-9.
2009
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| 18 | CHFR
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| Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer.
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| Oki E, Zhao Y, Yoshida R, Masuda T, Ando K, Sugiyama M, Tokunaga E, Morita M, Kakeji Y, Maehara Y.
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| World J Gastroenterol 15(20):2520-5.
2009
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| 19 | CHFR
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| CHFR promoter hypermethylation and reduced CHFR mRNA expression in ovarian cancer.
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| Gao Y, Lou G, Zhang GM, Sun XW, Ma YY, Yang YM, Liu G.
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| Int J Biol Markers 24(2):83-9.
2009
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| 20 | CHFR
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| Chfr is linked to tumour metastasis through the downregulation of HDAC1.
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| Oh YM, Kwon YE, Kim JM, Bae SJ, Lee BK, Yoo SJ, Chung CH, Deshaies RJ, Seol JH.
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| Nat Cell Biol 11(3):295-302. Epub 2009 Feb 1.
2009
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| 21 | CHFR, TPT1
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| Chfr interacts and colocalizes with TCTP to the mitotic spindle.
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| Burgess A, Labbé JC, Vigneron S, Bonneaud N, Strub JM, Van Dorsselaer A, Lorca T, Castro A.
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| Oncogene ncogene. 2008 May 26. [Epub ahead of print]PMID: 18504434 2008
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| 22 | AURKA, CHFR
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| Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint.
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| Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM.
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| Neoplasia 10(7):643-52.PMID: 18592005 2008
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| 23 | CHFR
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| Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.
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| Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC.
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| Nature 451(7174):81-5.
2008
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| 24 | CHFR, AURKA
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| Chfr is required for tumor suppression and Aurora A regulation.
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| Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J.
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| Nat Genet 37(4):401-6. Epub 2005 Mar 27. 2005
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| 25 | CHFR
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| Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma.
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| Sakai M, Hibi K, Kanazumi N, Nomoto S, Inoue S, Takeda S, Nakao A.
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| Hepatogastroenterology 52(66):1854-7. 2005
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| 26 | CHFR
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| Epigenetic inactivation of CHFR in human tumors.
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| Toyota M, Sasaki Y, Satoh A, Ogi K, Kikuchi T, Suzuki H, Mita H, Tanaka N, Itoh F, Issa JP, Jair KW, Schuebel KE, Imai K, Tokino T.
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| Proc Natl Acad Sci U S A 100(13):7818-23. Epub 2003 Jun 16. 2003
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| 27 | CHFR
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| Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer.
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| Corn PG, Summers MK, Fogt F, Virmani AK, Gazdar AF, Halazonetis TD, El-Deiry WS.
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| Carcinogenesis 24(1):47-51. 2003
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| 28 | CHFR
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| Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer.
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| Shibata Y, Haruki N, Kuwabara Y, Ishiguro H, Shinoda N, Sato A, Kimura M, Koyama H, Toyama T, Nishiwaki T, Kudo J, Terashita Y, Konishi S, Sugiura H, Fujii Y.
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| Carcinogenesis 23(10):1695-9. 2002
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| 29 | CHFR
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| The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
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| Kang D, Chen J, Wong J, Fang G.
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| J Cell Biol 156(2):249-59. 2002
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| 30 | CHFR
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| Chfr defines a mitotic stress checkpoint that delays entry into metaphase.
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| Scolnick DM, Halazonetis TD.
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| Nature 406(6794):430-5. 2000
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