| basic FUNCTION
| mediating protein-protein interactions |
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defining a checkpoint that delays entry into metaphase in response to mitotic stress |
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acting as an ubiquitin ligase (ubiquitinating Plk1) |
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inhibiting Cdc2 at the G2 to M transition |
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tumor suppressor controlling the expression of key mitotic proteins such STK6 |
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E3 ubiquitin ligase and early mitotic checkpoint protein implicated in many cancers and in the maintenance of genomic stability  |
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role for CHFR regulating chromosome segregation where decreased expression, as seen in cancer cells, contributes to genomic instability by impairing the spindle assembly checkpoint |
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checkpoint protein that plays an important function in cell cycle progression and tumor suppression |
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plays a role in the maintenance of genome integrity |
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promotes the ubiquitination of AURKA and PLK1 |
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may also promote the formation of 'Lys-63'-linked polyubiquitins chains and functions with the specific ubiquitin conjugating UBEN2-UBE2V2 heterodimer |
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negative regulator of the NF-KappaB pathway, downregulating IL8 production |
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binding and downregulating HDAC1 by inducing its polyubiquitination |
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functions as a mitotic checkpoint by delaying entry into metaphase in response to mitotic stress |
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plays an important role in regulation of HLTF stability and protects cells against HLTF-mediated cell migration |
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critical role for CHFR in the MAD2L1 spindle checkpoint |
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is one of the E3 ligases, which is known to be a tumor suppressor and play an essential role in cell cycle control and tumorigenesis |
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CHFR and RNF8 may have overlapping targets and/or functions in mitosis |
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RNF8 and CHFR affect chromatin relaxation and modulate ATM activation and DNA damage response pathways |
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RNF8 and CHFR, function together to activate ATM and maintain genomic stability |
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mediates the ubiquitination of the major components of the SWI/SNF complex (PMID; |
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PARP1 is a novel CHFR binding protein and found a functional interaction that regulates the early mitotic checkpoint and tumorigenesis |
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is an important E3 ligase in the early stage of the DNA damage response, which mediates the crosstalk between |
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important role in cell cycle progression and tumorigenesis |
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new regulatory mechanism for CHFR that sequential post-translational modifications of CHFR by SUMO and ubiquitin coordinately regulates its stability |
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ubiquitin ligase CHFR, that is a checkpoint protein involved in G2/M transition, and a new effector involved in the control of insulin-induced cell proliferation |
