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FLASH GENE

Symbol

NAP1L4

contributors: npt/ - updated : 01-07-2006

HGNC name	nucleosome assembly protein 1-like 4
HGNC id	7640

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : 2.965.660 - 3.013.607
Synonym name	nucleosome assembly protein 1-like 4b
Synonym symbol(s)	NAP2, NAP2L, hNAP2, MGC4565, NAP1L4b

DNA

TYPE	functioning gene
STRUCTURE	47.95 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

excluded of the imprinting domain

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005969 16 - 2564 NP_005960 - 375 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   mouth tongue     highly   salivary gland       highly Lymphoid/Immune spleen       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains	potential nuclear localization motif
	two clusters of highly acidic residues

HOMOLOGY

Homologene

FAMILY

nucleosome assembly protein (NAP) family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	localized mainly to the cytoplasm and a minor population of them was suggested to be in the nucleus (Okuwaki 2010)

basic FUNCTION	with NAP1L1 mediated nucleosome formation (Okuwaki 2010)
	play overlapping roles in transport and deposition of histone H2A-H2B or H2A variants-H2B dimers on chromatin and nonoverlapping roles in nucleosome disassembly (Okuwaki 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

core and linker histones

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS