| Symbol
| FBLIM1
| contributors: mct - updated : 26-06-2017
|
| HGNC name
| filamin binding LIM protein 1
|
| HGNC id
| 24686
|
| corresponding disease(s)
|
CRMO2
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
|
|
| |
increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma (Papachristou 2007) | | tumoral
|
|
| --over
|
|
is associated with poor prognosis for patients with glioma  | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| use of FBLIM1 as a molecular marker in glioma for early diagnosis and as an indicator of prognosis | | Therapy target
| therapeutic intervention targeting the migfilin signaling pathway may provide a novel approach to restore anoikis sensitivity and alleviate cancer progression (Zhao 2009) | |
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | digestive | liver | |
| is a potential therapeutic target against hepatocellular carcinoma metastasis (PMID:25773778) | | cancer | | | |
| therapeutic intervention targeting the migfilin signaling pathway may provide a novel approach to restore anoikis sensitivity and alleviate cancer progression |
| |
|
| inactivation of Fblim1 (the gene encoding Fblp-1) in mice resulted in a severe osteopenic phenotype |