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FLASH GENE
Symbol FBLIM1 contributors: mct - updated : 26-06-2017
HGNC name filamin binding LIM protein 1
HGNC id 24686
ASSOCIATED DISORDERS
corresponding disease(s) CRMO2
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional        
increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma (Papachristou 2007)
tumoral     --over  
is associated with poor prognosis for patients with glioma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • use of FBLIM1 as a molecular marker in glioma for early diagnosis and as an indicator of prognosis
  • Therapy target therapeutic intervention targeting the migfilin signaling pathway may provide a novel approach to restore anoikis sensitivity and alleviate cancer progression (Zhao 2009)
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    is a potential therapeutic target against hepatocellular carcinoma metastasis (PMID:25773778)
    cancer  
    therapeutic intervention targeting the migfilin signaling pathway may provide a novel approach to restore anoikis sensitivity and alleviate cancer progression
    ANIMAL & CELL MODELS
  • inactivation of Fblim1 (the gene encoding Fblp-1) in mice resulted in a severe osteopenic phenotype