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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CHD8

contributors: mct/shn - updated : 15-11-2023

HGNC name	chromodomain helicase DNA binding protein 8
HGNC id	20153

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Chd8–/– mouse embryos was arrested at gastrulation and died early during embryogenesis, manifesting widespread apoptosis, whereas deletion of p53 ameliorated this developmental arrest
	Chd8 +/- mice appeared normal and were fertile
	Complete loss of Chd8 causes embryonic lethality in mice as a result of TP53-mediated apoptosis