basic FUNCTION
| playing a crutial role in the insertion of secretory and membrane polypeptides into the ER |
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required for assembly of membrane and secretory proteins |
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SEC61A1 complexes that are present in the ER membrane of nucleated cells form calcium leak channels that may play a crucial role in calcium homeostasis |
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heterotrimeric SEC61A1 complex, which forms a dynamic polypeptide-conducting channel in the ER membrane |
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role for SEC61A1 in the formation of the minimal filtration unit of the kidney, the nephron |
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LONRF1, CDK1, RPL18, GNB2L1 (RACK1), RPL30, and SEC61A1 are crucial components in the diagnosis and treatment of Prostate carcinoma |