Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

LDHA

contributors: mct - updated : 11-05-2020

HGNC name	lactate dehydrogenase A
HGNC id	6535

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LDHAD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gastric cancer constitutional       loss of function inhibition of LDHA suppresses seizures constitutional     --other   increased LDHA/LDHB ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer urinary   targeting the PCK1/LDHA pathway might be a new strategy to selectively inhibit tumor metabolism in in clear cell renal cell carcinoma neurology     LDHA is a molecular target for the development of new antiepileptic drugs cancer reproductive breast repression of LDHA induced by TP53 blocks tumor growth and invasion through downregulation of aerobic glycolysis in breast cance cancer lung   can be a potential target for lung adenocarcinoma (LUAD) treatment cardiovascular atheroma   LDHA is a potential therapeutic target to prevent vessel lumen constriction during the course of atherosclerosis and restenosis cancer reproductive prostate LDHA might be a potential therapeutic target in prostate cancer

ANIMAL & CELL MODELS