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FLASH GENE

Symbol

KLC2

contributors: mct - updated : 08-09-2016

HGNC name	kinesin light chain 2
HGNC id	20716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001134775 16 - 3093 NP_001128247 69 622 - 2012 22470497 NM_001134774 15 - 2733 NP_001128246 60 545 - 2012 22470497 NM_022822 16 - 3067 NP_073733 69 622 - 2012 22470497 NM_001134776 16 - 2972 NP_001128248 69 622 - 2012 22470497

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal domain made of heptad repeats typical of the rod domain of cytoskeletal proteins
	a central and C terminal consisting of 27-mer repeats of approximatively 21 aminoacids
	tetratricopeptide repeat (TPR) domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to purple sea urchin Spklc

Homologene

FAMILY

kinesin light chain family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	is a cellular target of GSK3B capable of regulating synaptic plasticity, particularly AMPA receptor trafficking
	acts as a proto-oncogene in non-small-cell lung cancer (NSCLC) cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

component of a complex with two kinesins, heavy chain and two light chains (KIF5A, KIF5B, KLC2, KLC1) (Morton 2010)

INTERACTION

DNA

RNA

small molecule

protein	LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3&
	946; (GSK3B)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPOAN

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small-cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS