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FLASH GENE
Symbol KLC2 contributors: mct - updated : 08-09-2016
HGNC name kinesin light chain 2
HGNC id 20716
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain made of heptad repeats typical of the rod domain of cytoskeletal proteins
  • a central and C terminal consisting of 27-mer repeats of approximatively 21 aminoacids
  • tetratricopeptide repeat (TPR) domains
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to purple sea urchin Spklc
    Homologene
    FAMILY
  • kinesin light chain family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • is a cellular target of GSK3B capable of regulating synaptic plasticity, particularly AMPA receptor trafficking
  • acts as a proto-oncogene in non-small-cell lung cancer (NSCLC) cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of a complex with two kinesins, heavy chain and two light chains (KIF5A, KIF5B, KLC2, KLC1) (Morton 2010)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3&
  • 946; (GSK3B)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPOAN
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small-cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS