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FLASH GENE

Symbol

KLC2

contributors: mct - updated : 08-09-2016

HGNC name	kinesin light chain 2
HGNC id	20716

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	SPOAN spastic paraplegia, congenital optic atrophy, neuropathy
Location	11q13.2      Physical location : 66.024.764 - 66.035.332
Synonym name	kinesin,light chain 2, likely ortholog of mouse Klc2
Synonym symbol(s)	FLJ12387

DNA

TYPE	functioning gene
STRUCTURE	10.57 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001134775 16 - 3093 NP_001128247 69 622 - 2012 22470497 NM_001134774 15 - 2733 NP_001128246 60 545 - 2012 22470497 NM_022822 16 - 3067 NP_073733 69 622 - 2012 22470497 NM_001134776 16 - 2972 NP_001128248 69 622 - 2012 22470497

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal domain made of heptad repeats typical of the rod domain of cytoskeletal proteins
	a central and C terminal consisting of 27-mer repeats of approximatively 21 aminoacids
	tetratricopeptide repeat (TPR) domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to purple sea urchin Spklc

Homologene

FAMILY

kinesin light chain family

CATEGORY

motor/contractile

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule

basic FUNCTION	is a cellular target of GSK3B capable of regulating synaptic plasticity, particularly AMPA receptor trafficking
	acts as a proto-oncogene in non-small-cell lung cancer (NSCLC) cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

component of a complex with two kinesins, heavy chain and two light chains (KIF5A, KIF5B, KLC2, KLC1) (Morton 2010)

INTERACTION

DNA

RNA

small molecule

protein	LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3&
	946; (GSK3B)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPOAN

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small-cell lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS