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FLASH GENE

Symbol

PPIG

contributors: - updated : 22-12-2005

HGNC name	peptidyl-prolyl isomerase G (cyclophilin G)
HGNC id	14650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	serine/arginine (S/R) dipeptide repeats in the C-terminus
	a highly conserved polypeptide signature segment (the MOCA domain), which may well be involved in the functional regulation at the C-terminal tail, and
	five CDC2-type phosphorylation sites gathered in and around the MOCA domain

HOMOLOGY

Homologene

FAMILY	cyclophilin-type ppiase family, CYP-40 subfamily
	MOCA family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	predominantly diffuse cytoplasmic distribution at the onset of mitosis, and in late telophase recruited to the newly formed nuclei

basic FUNCTION	catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
	cell cycle-regulated cyclophilin
	may be implicated in the folding, transport, and assembly of proteins and may play an important role in the regulation of pre-mRNA splicing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS