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FLASH GENE
Symbol PPIG contributors: - updated : 22-12-2005
HGNC name peptidyl-prolyl isomerase G (cyclophilin G)
HGNC id 14650
DNA
TYPE functioning gene
STRUCTURE 53.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Endocrinepancreas    
Nervousspinal cord    
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text pancreas
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • serine/arginine (S/R) dipeptide repeats in the C-terminus
  • a highly conserved polypeptide signature segment (the MOCA domain), which may well be involved in the functional regulation at the C-terminal tail, and
  • five CDC2-type phosphorylation sites gathered in and around the MOCA domain
  • HOMOLOGY
    Homologene
    FAMILY
  • cyclophilin-type ppiase family, CYP-40 subfamily
  • MOCA family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text predominantly diffuse cytoplasmic distribution at the onset of mitosis, and in late telophase recruited to the newly formed nuclei
    basic FUNCTION
  • catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
  • cell cycle-regulated cyclophilin
  • may be implicated in the folding, transport, and assembly of proteins and may play an important role in the regulation of pre-mRNA splicing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS