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FLASH GENE

Symbol

PPIG

contributors: - updated : 22-12-2005

HGNC name	peptidyl-prolyl isomerase G (cyclophilin G)
HGNC id	14650

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	53.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus         Endocrine pancreas         Nervous spinal cord         Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid         Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	serine/arginine (S/R) dipeptide repeats in the C-terminus
	a highly conserved polypeptide signature segment (the MOCA domain), which may well be involved in the functional regulation at the C-terminal tail, and
	five CDC2-type phosphorylation sites gathered in and around the MOCA domain

HOMOLOGY

Homologene

FAMILY	cyclophilin-type ppiase family, CYP-40 subfamily
	MOCA family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	predominantly diffuse cytoplasmic distribution at the onset of mitosis, and in late telophase recruited to the newly formed nuclei

basic FUNCTION	catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
	cell cycle-regulated cyclophilin
	may be implicated in the folding, transport, and assembly of proteins and may play an important role in the regulation of pre-mRNA splicing

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS