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FLASH GENE

Symbol

FOXQ1

contributors: mct - updated : 03-12-2015

HGNC name	forkhead box Q1
HGNC id	20951

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033260 1 - 2338 - 403 - 2001 11747606

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           salivary gland           stomach         Respiratory lung           respiratory tract trachea       Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	neuroblasts derived from procephalic region, ventral nervous system, thoracic sensory neurons and brain cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two putative transcriptional activation domain
	one fork-head DNA-binding domain

HOMOLOGY

interspecies

ortholog to murine Foxq1

Homologene

FAMILY

member of the cancer-related FOX family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	involved in development during embryogenesis
	HOXC13 and FOXQ1 control medulla differentiation of the hair through a common regulatory pathway
	potential functional roles, for epithelial plasticity
	involved in regulation of transcription, DNA-dependent
	critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells
	FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin (CDH1)
	a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer
	FOXC1, GMDS, FOXF2, and FOXQ1 may represent loci for enhancer-driven changes in gene expression that could affect the developing embryo

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	FOXF1 and FOXQ1 directly bind to distinct regions of MYOCD
	directly bound to the SOX12 promoter and transactivated its expression, which contributed to SOX12 overexpression in human hepatocellular carcinoma

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal and lung carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS