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FLASH GENE
Symbol KRT1 contributors: mct/npt - updated : 20-10-2016
HGNC name keratin 1
HGNC id 6412
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central rod domain
  • four helical domains (1A, 1B, 2A, 2B)
  • non alpha helical linkers (L1, 2, 3)
  • the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)
    • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • also acting as a binding protein and presentation for kininogens on endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT10, also with KRT9
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exogenous FABP4 interacts with plasma membrane proteins, specifically KRT1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EHK1 , IHCM , PPKS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS