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FLASH GENE
Symbol KRT1 contributors: mct/npt - updated : 20-10-2016
HGNC name keratin 1
HGNC id 6412
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text type II cytokeratins are clustered in a region of chromosome 12q12-q13
STRUCTURE 5.67 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 2451 66 644 - Schweizer (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx    
Lymphoid/Immunethymus    
Skin/Tegumentskin    
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningepidermisstratum spinosum 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central rod domain
  • four helical domains (1A, 1B, 2A, 2B)
  • non alpha helical linkers (L1, 2, 3)
  • the homology domains H1 and H2, by variable region (V1, V2) and end sequences (E1, E2)
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • also acting as a binding protein and presentation for kininogens on endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT10, also with KRT9
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • exogenous FABP4 interacts with plasma membrane proteins, specifically KRT1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EHK1 , IHCM , PPKS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS