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FLASH GENE
Symbol UTP4 contributors: mct - updated : 08-12-2010
HGNC name UTP4 small subunit processome component
HGNC id 1983
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal mitochondrial targeting peptide
  • ten WD repeats
  • C-terminal monopartite nuclear localization signal (NLS), potentially required for ribosome biogenesis
    • HOMOLOGY
    interspecies ortholog to murine Cirh1a
    Homologene
    FAMILY
    CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • WD repeat protein may be involved in signal transduction
  • transcriptional regulatory factor of NF-kappaB sequence and could be a participant in the regulation of other genes with NF-kappaB responsive elements (up-regulates a canonical NF-kappaB element through strong interaction with HIVEP1)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIVEP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NAIC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS