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FLASH GENE
Symbol UTP4 contributors: mct - updated : 08-12-2010
HGNC name UTP4 small subunit processome component
HGNC id 1983
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
Digestiveliver    
 mouthtongue   
 stomach    
Lymphoid/Immunethymus    
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Respiratoryrespiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye, liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal mitochondrial targeting peptide
  • ten WD repeats
  • C-terminal monopartite nuclear localization signal (NLS), potentially required for ribosome biogenesis
  • HOMOLOGY
    interspecies ortholog to murine Cirh1a
    Homologene
    FAMILY
    CATEGORY regulatory , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • WD repeat protein may be involved in signal transduction
  • transcriptional regulatory factor of NF-kappaB sequence and could be a participant in the regulation of other genes with NF-kappaB responsive elements (up-regulates a canonical NF-kappaB element through strong interaction with HIVEP1)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIVEP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NAIC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS