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FLASH GENE

Symbol

NLRP6

contributors: mct/pgu - updated : 18-08-2012

HGNC name	NLR family, pyrin domain containing 6
HGNC id	22944

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	NLRP6 expression and PYCARD methylation may represent unique molecular markers of carcinogenesis
Therapy target
	System Type Disorder Pubmed cancer digestive colon continuous stimulation of NLRP6 may represent a promising therapeutical strategy in Colorectal carcinoma immunology inflammatory   continuous stimulation of NLRP6 may represent a promising therapeutical strategy in inflammatory bowel diseases immunology infectious   therapeutic inhibition of NLRP6 activation may prove beneficial for treating infectious diseases

ANIMAL & CELL MODELS

	Nlrp6 inflammasome-deficient mice were characterized by spontaneous intestinal hyperplasia, inflammatory cell recruitment
	Nlrp6-deficient mice were highly resistant to infection with the bacterial pathogens Listeria monocytogenes, Salmonella typhimurium and Escherichia coli, and infected Nlrp6-deficient mice had increased numbers of monocytes and neutrophils in circulation