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FLASH GENE

Symbol

WNT3

contributors: shn/mct - updated : 06-11-2018

HGNC name	wingless-type MMTV integration site family, member 3
HGNC id	12782

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

TETAMS1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast and rectal cancer tumoral     --over   during the progression of non-small cell lung cancer (NSCLC), WNT3 overexpression could be associated with the development of more aggressive tumors

Susceptibility

to non-syndromic cleft lip with or without cleft palate (NSCL/P)

Variant & Polymorphism SNP	rs3809857 and rs9890413 polymorphisms of WNT3 appeared to be associated with NSCL/P

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Wnt3-/- mice develop a normal egg cylinder but do not form a primitive streak, mesoderm or node (Liu et al, 1999)