Symbol
| WNT3
| contributors: shn/mct - updated : 06-11-2018
|
HGNC name
| wingless-type MMTV integration site family, member 3
|
HGNC id
| 12782
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
in breast and rectal cancer | tumoral
|  
|  
| --over
|  
|
during the progression of non-small cell lung cancer (NSCLC), WNT3 overexpression could be associated with the development of more aggressive tumors | |
Susceptibility
|
to non-syndromic cleft lip with or without cleft palate (NSCL/P) |
Variant & Polymorphism
SNP
| rs3809857 and rs9890413 polymorphisms of WNT3 appeared to be associated with NSCL/P |
|
|
Candidate gene
Marker
Therapy target
| | | |
| Wnt3-/- mice develop a normal egg cylinder but do not form a primitive streak, mesoderm or node (Liu et al, 1999) |