| basic FUNCTION
| modulating cell fate and cell behavior during vertebrate development |
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required for the primary axis formation, for urogenital, limb, and craniofacial development |
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may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway |
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involved in tumorigenesis |
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acts as a retrograde signal that controls terminal arborization of muscle afferents (Krylova et al, 2002) |
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acts as an intrinsic regulator of hippocampal neurogenesis by modulating the generation of newborn neurons in the adult dentate gyrus (Zhou et al, 2004) |
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acts as an axon guidance molecule and plays a role in retinotectal mapping along the medial-lateral axis (Schmitt et al, 2006) |
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functions as a modulator of postsynaptic differentiation at the vertebrate peripheral neuromuscular synapses by collaborating with agrin (Henriquez et al, 2008) |
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both the levels of WNT3 protein and the number of WNT3-secreting astrocytes influence the impairment of adult neurogenesis during aging  |
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is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs |
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novel role for WNT3 as a regulator of neurogenesis and repressor of neural tumors |
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WNT3 and WNT5B are critical factors secreted from Transforming growth factor-induced mesenchymal cancer cells for instigating the epithelial cancer cell invasion along with the induction of secondary EMT phenotype |
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WNT3 and membrane-associated CTNNB1 regulate trophectoderm lineage differentiation in human blastocysts |
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YAP1 maintains hESC pluripotency by preventing WNT3 expression in response to Activin, thereby blocking a direct route to embryonic cardiac mesoderm formation |
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is an important modulator of axon regeneration, and is a key intrinsic regulator of axon growth ability of the nervous system |
