basic FUNCTION
| may play important roles in mammalian development |
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functions in epithelial cell maintenance throughout life |
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acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation |
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cooperative roles of the GRHL genes in epidermal development |
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regulates neural tube closure and adhesion molecule expression during neural fold fusion |
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major role for GRHL2 in the suppression of oncogenic EMT in breast cancer cells |
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transcription factor that regulates the size of luminal space surrounded by polarized epithelial cells |
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GRHL2 and NKX2-1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation |
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transcription factor that regulates TERT gene expression and enhances proliferation of normal human epidermal keratinocytes |
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crucial role of GRHL2 in epithelial activation in lung fibrosis and perhaps also in epithelial plasticity |
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play essential roles during epithelial development |
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conserved Grhl2-coordinated gene network controls trophoblast branching morphogenesis, thereby facilitating development of the site of feto-maternal exchange |
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acts as a transcriptional activator and strongly associates with histone H3 lysine 4 trimethylation |
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GRHL2/OVOL2 network controlling CLDN4 and RAB25 expression that facilitates lumen expansion and barrier formation in subtypes of renal epithelia |
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play a number of roles in ectoderm development and maintenance in mammals |
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has an important role in epithelial morphogenesis through trans-activation of genes required for the formation of the apical junctional complex and repression of EMT |