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FLASH GENE
Symbol CADM3 contributors: mct - updated : 15-12-2010
HGNC name cell adhesion molecule 3
HGNC id 17601
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three immunoglobulin-like domains
  • a single transmembrane domain
  • a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif
  • single N-glycosylation site at N290KS which influences its adhesion activity
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Igsf4b
    intraspecies homolog to TSLC1
    Homologene
    FAMILY
  • Ca-independent immunoglobulin superfamily of cell adhesion molecules
  • nectin-like family
    • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • functioning as adhesion molecule
  • playing an important role for mediating axon-glia contact during myelination in peripheral nerves
  • could play an important role in cell-cell interaction as well as in tumor suppression
  • mediate critical interactions between Schwann cells and axons during myelination
  • has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity, and plays an important role in the formation of synapses, axon bundles, and myelinated axons
  • neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons
  • may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
  • with CADM4, suppress the growth and tumorigenic ability of colon cancer cells
  • plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    G-protein coupled receptor protein signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding partner for CADM4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in glioma and prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS