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FLASH GENE

Symbol

CADM3

contributors: mct - updated : 15-12-2010

HGNC name	cell adhesion molecule 3
HGNC id	17601

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	31.56 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001127173 9 - 3559 NP_001120645 - 398 - 2003 14659875 NM_021189 10 - 3698 NP_067012 - 432 - 2003 14659875

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine       Homo sapiens   intestine small intestine       Homo sapiens Nervous brain       predominantly Homo sapiens   brain hindbrain cerebellum   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Homo sapiens Nervous peripherous       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, fetal brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	three immunoglobulin-like domains
	a single transmembrane domain
	a short cytosolic tail with a protein 4.1 interaction sequence and a PDZ type II motif
	single N-glycosylation site at N290KS which influences its adhesion activity

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Igsf4b

intraspecies

homolog to TSLC1

Homologene

FAMILY	Ca-independent immunoglobulin superfamily of cell adhesion molecules
	nectin-like family

CATEGORY

adhesion , receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	functioning as adhesion molecule
	playing an important role for mediating axon-glia contact during myelination in peripheral nerves
	could play an important role in cell-cell interaction as well as in tumor suppression
	mediate critical interactions between Schwann cells and axons during myelination
	has Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity, and plays an important role in the formation of synapses, axon bundles, and myelinated axons
	neural tissue-specific immunoglobulin-like cell-cell adhesion molecule which has Ca(2+)-independent homo- or heterophilic cell-cell adhesion activity and plays an important role in the formation of synapses, axon bundles and myelinated axons
	may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
	with CADM4, suppress the growth and tumorigenic ability of colon cancer cells
	plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

G-protein coupled receptor protein signaling pathway

a component

INTERACTION

DNA

RNA

small molecule

protein

binding partner for CADM4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in glioma and prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS