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FLASH GENE

Symbol

ZFR

contributors: mct - updated : 28-12-2018

HGNC name	zinc finger RNA binding protein
HGNC id	17277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016107 20 - 4759 NP_057191 - 1074 - 2001 11574164

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Homo sapiens Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three central C2H2-type zinc finger motifs

HOMOLOGY

interspecies

ortholog to murine Zfr

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	ZFR is a native component of STAU2-containing granules and likely plays its role during early steps of RNA transport and localization
	is involved in the regulation of growth and cancer development
	critical role of ZFR in NSCLC tumor growth and metastasis, by targeting the NOTCH1 signaling pathway
	ZFR represses the interferon response by regulating alternative pre-mRNA splicing
	regulation of ZFR in macrophage differentiation guards against aberrant interferon responses, suggesting a network of mRNA processing and decay that shapes the transcriptional response to infection

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with RNPS1
	ZFR, a three zinc finger protein, was identified as an interacting protein of STAU2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG71

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in non-small-cell lung carcinoma (NSCLC) cells tumoral     --over   significantly higher in pancreatic tumors than normal pancreas tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   is a promising therapeutic target in metastatic NSCLC cancer endocrine pancreas knockdown of ZFR suppresses cell proliferation and invasion of human pancreatic cance

ANIMAL & CELL MODELS