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FLASH GENE
Symbol EPOR contributors: mct - updated : 17-01-2018
HGNC name erythropoietin receptor
HGNC id 3416
ASSOCIATED DISORDERS
corresponding disease(s) ECYT1
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral       gain of function
activated cell proliferation pathways in melanoma cells and resulted in increased cell proliferation and resistance to hypoxia and cisplatin treatment
Susceptibility
Variant & Polymorphism
Candidate gene unlikely involved in Diamond-Blackfan anemia
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascularaquired 
EPO/EPOR is a novel therapeutic target in cardiovascular disease
ANIMAL & CELL MODELS
  • macrophage-specific Epor(-/-) mice developed lupus-like symptoms, and interference in EPO signaling ameliorated the disease progression in lupus-like mice