protein
| JAK2 and STAT5, STAT3, STAT1 binding (for activation) |
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TFR2 is a component of the EPOR complex |
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GATA4 is novel regulator of EPOR transcription in cardiomyocytes |
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EPO binds to EPOR, initiating signaling that stimulates growth, inhibits apoptosis, and induces the differentiation of erythroid progenitors to increase red blood cell mass |
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interaction between SH2B1 and EPOR (SH2B1 becomes phosphorylated in response to EPO and acts as a negative regulator of signaling downstream of the EPOR) |
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forced TAL1 expression increases EPOR and erythropoietin hypersensitivity in erythroid progenitors |
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TAL1 can recruit GATA1 and increase GATA1 binding to the EPOR promoter region to stimulate gene expression |
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SP1 may significantly affect the number of EPOR molecules present on the surface of activated CD4(+) lymphocytes |
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EPO induces the expression of myelin genes in oligodendrocytes and this effect requires the presence of EPOR |
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CBL ubiquitination of PIK3R1 is essential for EPO-induced EPOR endocytosis |
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VEGFA activates EPOR and enhances VEGFR2-mediated pathological angiogenesis |
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EPO binds to the EPOR homodimer on the surface of erythroid progenitors and erythroblasts, and positions the intracellular domains of the homodimer to be in close proximity with each other |
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CSF2RB colocalized and interacted with EPO receptor (EPOR) in macrophages |
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EPO had enhanced carcinogenesis through increase of EPOR and FLT1 expression, and thereby contributed to tumor development |
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EPOR regulates development of blood cells, and its full activation normally requires the cytokine erythropoietin EPO |
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EPO mediates its erythropoietic function through a homodimeric EPO receptor (EPOR) that is also widely expressed in the nervous system |