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| Newborn mice with IgfI null mutation exhibit a growth deficiency die shortly after birt or can each adulthood ( | |
mice with severe IGF-1 deficiency display elevated blood pressure and enhanced myocardial contractility ( |
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profound embryonic and postnatal growth retardation in IGF1 knockout mice |
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normoglycemic/normoinsulinemic transgenic mice overexpressing IGF-1 in the retina developed most alterations observed in human diabetic eye disease ( |
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mice lacking both Insr and Ifg1r developed diabetes in contrast to mild phenotypes observed in single mutants |
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IGF1 knockout mice have defects in neurologic development |
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IGF1 decreased photoreceptor apoptosis in rd1 mouse retinal explants in parallel with reduced activation of calpain-2 and increased levels of calpastatin and activation of phospho-CREB ( |
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