Citations for
1IGF1, IGFBP2, PTPRZ1
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Xi G, Shen X, Rosen CJ, Clemmons DR.
J Bone Miner Res Bone Miner Res. 2016 Jan 16. doi: 10.1002/jbmr.2791. [Epub ahead of print] 2016
2IGF1, IGFBP2
IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation.
Xi G, Rosen CJ, Clemmons DR.
Endocrinology 157(1):268-81. doi: 10.1210/en.2015-1690. Epub 2015 Nov 10. 2016
3IGF1, MEF2D
The involvement of myocyte enhancer factor 2D in regulating tumor biology of cardiac myxoma.
Huo Y, Zhao Q, Wang C, Zhao F, Du Y, Sun W.
Tumour Biol 37(4):5405-11. doi: 10.1007/s13277-015-4386-y. Epub 2015 Nov 12. 2016
4IGFBP2, IRS1, iGF1
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Xi G, Shen X, Rosen CJ, Clemmons DR.
J Bone Miner Res 31(6):1300-14. doi: 10.1002/jbmr.2791. Epub 2016 Feb 20. 2016
5IGF1, IGFBP2, PPARA
Regulation of IGFBP-2 expression during fasting.
Kang HS, Kim MY, Kim SJ, Lee JH, Kim YD, Seo YK, Bae JH, Oh GT, Song DK, Ahn YH, Im SS.
Biochem J 467(3):453-60. doi: 10.1042/BJ20141248. 2015
6CREB1, IGF1, MSTN
The cAMP response element binding protein (CREB) is activated by insulin-like growth factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast.
Zuloaga R, Fuentes EN, Molina A, Valdés JA.
Biochem Biophys Res Commun 440(2):258-64. doi: 10.1016/j.bbrc.2013.09.067. Epub 2013 Sep 21. 2013
7IGF1, MUC5B, MUC8
Insulin-like growth factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells.
Bae CH, Kim JS, Song SY, Kim YW, Park SY, Kim YD.
Biochem Biophys Res Commun 430(2):683-8. doi: 10.1016/j.bbrc.2012.11.091. Epub 2012 Dec 2. 2013
8GPER1, IGF1
Insulin-like growth factor-I regulates GPER expression and function in cancer cells.
De Marco P, Bartella V, Vivacqua A, Lappano R, Santolla MF, Morcavallo A, Pezzi V, Belfiore A, Maggiolini M.
Oncogene 32(6):678-88. doi: 10.1038/onc.2012.97. Epub 2012 Mar 19. 2013
9IGF1, MEX3C
Mex3c mutation reduces adiposity and increases energy expenditure.
Jiao Y, George SK, Zhao Q, Hulver MW, Hutson SM, Bishop CE, Lu B.
Mol Cell Biol 32(21):4350-62. doi: 10.1128/MCB.00452-12. Epub 2012 Aug 27. 2012
10IGF1
Local insulin-like growth factor I expression is essential for Purkinje neuron survival at birth.
Croci L, Barili V, Chia D, Massimino L, van Vugt R, Masserdotti G, Longhi R, Rotwein P, Consalez GG.
Cell Death Differ. 18(1):48-59. 2011
11IGF1, SYT10, SYT3, SYT5, SYT6
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10.
Cao P, Maximov A, Südhof TC.
Cell 145(2):300-11. 2011
12GH1, IGF1
Common polymorphisms in the GH/IGF-1 axis contribute to growth in extremely tall subjects.
Hendriks AE, Brown MR, Boot AM, Oostra BA, de Jong FH, Drop SL, Parks JS.
Growth Horm IGF Res 21(6):318-24. doi: 10.1016/j.ghir.2011.08.001. Epub 2011 Sep 25. 2011
13GH1, IGF1, RELA
Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2.
Wu S, Morrison A, Sun H, De Luca F.
J Biol Chem 286(28):24726-34. Epub 2011 May 18. 2011
14IGF1, IGF1D
Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene.
van Duyvenvoorde HA, van Setten PA, Walenkamp MJ, van Doorn J, Koenig J, Gauguin L, Oostdijk W, Ruivenkamp CA, Losekoot M, Wade JD, De Meyts P, Karperien M, Noordam C, Wit JM.
J Clin Endocrinol Metab 95(11):E363-7. Epub 2010 Jul 28. 2010
15GH1, IGF1
GH and IGF1 levels are positively associated with musculotendinous collagen expression: experiments in acromegalic and GH deficiency patients.
Doessing S, Holm L, Heinemeier KM, Feldt-Rasmussen U, Schjerling P, Qvortrup K, Larsen JO, Nielsen RH, Flyvbjerg A, Kjaer M.
Eur J Endocrinol 163(6):853-62. Epub 2010 Sep 21. 2010
16BRSK1, BRSK2, CDC42, DCX, DOCK7, DPYSL2, GSK3A, GSK3B, IGF1, KIF13B, KIF2A, KLC1, LIS1, MAP1B, MAP2, MAPK8, MAPT, NIN, PAFAH1B1, SCG10, SCLIP, STK11, STMN1, STMN2, STMN3, STRADA
Microtubule assembly, organization and dynamics in axons and dendrites.
Conde C, Caceres A.
Nat Rev Neurosci. 10(5):319-32. 2009
17IGF1, IGFBP3
Predictors of variation in serum IGF1 and IGFBP3 levels in healthy African American and white men.
Hoyo C, Grubber J, Demark-Wahnefried W, Lobaugh B, Jeffreys AS, Grambow SC, Marks JR, Keku TO, Walther PJ, Schildkraut JM.
J Natl Med Assoc 101(7):711-6. 2009
18IGF1, IGF1R
Familial short stature caused by haploinsufficiency of the insulin-like growth factor i receptor due to nonsense-mediated messenger ribonucleic acid decay.
Fang P, Schwartz ID, Johnson BD, Derr MA, Roberts CT Jr, Hwa V, Rosenfeld RG.
J Clin Endocrinol Metab 94(5):1740-7. Epub 2009 Feb 24. 2009
19IGF1
Role of insulin-like growth factor-1 (IGF-1) in regulating cell cycle progression.
Ma QL, Yang TL, Yin JY, Peng ZY, Yu M, Liu ZQ, Chen FP.
Biochem Biophys Res Commun 389(1):150-5. Epub 2009 Aug 26. 2009
20EGF, IGF1
Pattern of distribution of IGF-1 and EGF in pancreatic islets of type 2 diabetic patients.
Al-Salam S, Hameed R, Parvez H, Adeghate E.
Islets 1(2):102-5. 2009
21CAST, IGF1
IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death.
Arroba AI, Wallace D, Mackey A, de la Rosa EJ, Cotter TG.
Eur J Neurosci 30(6):975-86. Epub 2009 Sep 1. 2009
22ESR2, IGF1
Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians.
Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW.
Eur J Hum Genet 16(11):1380-7. Epub 2008 Jun 18. 2008
23IFNG, IGF1
In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth.
Conti L, Regis G, Longo A, Bernabei P, Chiarle R, Giovarelli M, Novelli F.
Blood 109(6):2496-504. Epub 2006 Dec 5. 2007
24IGFALS, IGF1R, IGFBP3, IGF1
Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study.
Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W.
Breast Cancer Res Treat 104(3):309-19. Epub 2006 Oct 25. 2007
25IGF1, SLC12A4, SLC12A5, SLC12A6, SLC12A7
IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.
Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR.
J Cell Physiol 210(3):626-36. 2007
26IGF1, SLC2A3
IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1.
Copland JA, Pardini AW, Wood TG, Yin D, Green A, Bodenburg YH, Urban RJ, Stuart CA.
Biochim Biophys Acta 1769(11-12):631-40. Epub 2007 Sep 4. 2007
27IGF1, IGFBP3
IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer.
Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA, Luccarini C, Munday H, Perkins B, Smith P, Pharoah PD, Wareham NJ, Easton DF, Ponder BA, Dunning AM.
Hum Mol Genet 15(1):1-10. Epub 2005 Nov 23. 2006
28IGF1, VEGFA
IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma.
Slomiany MG, Black LA, Kibbey MM, Day TA, Rosenzweig SA.
Biochem Biophys Res Commun 342(3):851-8. Epub 2006 Feb 20. 2006
29GH1, GHIS3, IGF1, IGF1D, IGHD1, IGHD2, STAT5B
Genetic disorders in the growth hormone - insulin-like growth factor-I axis.
Walenkamp MJ, Wit JM.
Horm Res 66(5):221-30. Review. 2006
30IGF1
Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
Ueki, K.; Okada, T.; Hu, J.; Liew, C. W.; Assmann, A.; Dahlgren, G. M.; Peters, J. L.; Shackman, J. G.; Zhang, M.; Artner, I.; Satin, L. S.; Stein, R.; Holzenberger, M.; Kennedy, R. T.; Kahn, C. R.; Kulkarni, R. N.
Nature Genet. 38: 583-588 2006
31IGF1, IGF1D
Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation.
Walenkamp MJ, Karperien M, Pereira AM, Hilhorst-Hofstee Y, van Doorn J, Chen JW, Mohan S, Denley A, Forbes B, van Duyvenvoorde HA, van Thiel SW, Sluimers CA, Bax JJ, de Laat JA, Breuning MB, Romijn JA, Wit JM.
J Clin Endocrinol Metab 90(5):2855-64. Epub 2005 Mar 15. 2005
32IGF1, SOCS3
SOCS-3 induces myoblast differentiation.
Spangenburg EE.
J Biol Chem 280(11):10749-58. Epub 2005 Jan 14. 2005
33SIRPA, SHC1, PTPN11, IGF1
Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells.
Ling Y, Maile LA, Lieskovska J, Badley-Clarke J, Clemmons DR.
Mol Biol Cell 16(7):3353-64. Epub 2005 May 11. 2005
34IGF1, IGFBP3
IGF-I and IGFBP-3 polymorphisms and risk of prostate cancer.
Friedrichsen DM, Hawley S, Shu J, Humphrey M, Sabacan L, Iwasaki L, Etzioni R, Ostrander EA, Stanford JL.
Prostate 65(1):44-51. 2005
35PTK6, IGF1, IRS4
Interaction between Brk kinase and insulin receptor substrate-4.
Qiu H, Zappacosta F, Su W, Annan RS, Miller WT.
Oncogene 24(36):5656-64. 2005
36IGF1
Insulin-like growth factor I is required for vessel remodeling in the adult brain.
Lopez-Lopez C, LeRoith D, Torres-Aleman I.
Proc Natl Acad Sci U S A 101(26):9833-8. Epub 2004 Jun 21. 2004
37IGF1
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease.
Ruberte, J.; Ayuso, E.; Navarro, M.; Carretero, A.; Nacher, V.; Haurigot, V.; George, M.; Llombart, C.; Casellas, A.; Costa, C.; Bosch, A.; Bosch, F.
J. Clin. Invest. 113: 1149-1157 2004
38IGF1, IGF1D
A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency.
Bonapace G, Concolino D, Formicola S, Strisciuglio P.
J Med Genet 40(12):913-7. No abstract available. 2003
39ACTG1, COL1A1, COL1A2, COL2A1, COL9A1, DIO2, HSPA8, IBSP, IGF1, KAT6B, OGN, POU3F4, RBMS3, VIM, ZIC2
Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs.
Luijendijk MW, van de Pol TJ, van Duijnhoven G, den Hollander AI, ten Caat J, van Limpt V, Brunner HG, Kremer H, Cremers FP.
Genomics 82(4):480-90. 2003
40IGF1
Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight.
Vaessen N, Janssen JA, Heutink P, Hofman A, Lamberts SW, Oostra BA, Pols HA, van Duijn CM.
Lancet 359(9311):1036-7. 2002
41IGF1, PIN1
IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry.
You H, Zheng H, Murray SA, Yu Q, Uchida T, Fan D, Xiao ZX.
J Cell Biochem 84(2):211-6. 2002
42IGF1, VEGFA
Insulin-like growth factor-I protects neuroblastoma against starvation-induced apoptosis and is associated with increased Bcl-2 expression.
Beierle EA, Strande LF, Chen MK.
J Pediatr Surg 37(3):472-6. 2002
43IGF1
IGF-1 up-regulates K+ channels via PI3-kinase, PDK1 and SGK1.
Gamper N, Fillon S, Huber SM, Feng Y, Kobayashi T, Cohen P, Lang F.
Pflugers Arch 443(4):625-34. 2002
44IGF1
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction.
Vaessen N, Heutink P, Janssen JA, Witteman JC, Testers L, Hofman A, Lamberts SW, Oostra BA, Pols HA, van Duijn CM.
Diabetes 50(3):637-42. 2001
45IGF1
Synthesis and characterization of insulin-like growth factor (IGF)-1 photoprobes selective for the IGF-binding proteins (IGFBPS). photoaffinity labeling of the IGF-binding domain on IGFBP-2.
Horney MJ, Evangelista CA, Rosenzweig SA.
J Biol Chem. 276(4):2880-9 2001
46IGF1, IGFBP3
Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): demonstration of IGF-I/IGFBP-3/fn ternary complexes in human plasma.
Gui Y, Murphy LJ.
J Clin Endocrinol Metab. 86(5):2104-10. 2001
47IGF1, IGF1D
Effects of insulin-like growth factor I (IGF-I) therapy on body composition and insulin resistance in IGF-I gene deletion.
Woods KA, Camacho-Hubner C, Bergman RN, Barter D, Clark AJ, Savage MO.
J Clin Endocrinol Metab 85(4):1407-11. 2000
48IGF1, IGF1D
Effects of recombinant human insulin-like growth factor I (IGF-I) therapy on the growth hormone-IGF system of a patient with a partial IGF-I gene deletion.
Camacho-Hubner C, Woods KA, Miraki-Moud F, Hindmarsh PC, Clark AJ, Hansson Y, Johnston A, Baxter RC, Savage MO.
J Clin Endocrinol Metab 84(5):1611-6. 1999
49ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
Sequence diversity in 36 candidate genes for cardiovascular disorders.
Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
Am J Hum Genet 65(1):183-91. 1999
50TNF, IGF1
A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide.
Venters HD, et al.
Proc Natl Acad Sci U S A 96(17):9879-84 1999
51TNF, IGF1
Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1.
Loddick SA, et al.
Proc Natl Acad Sci U S A 96(17):9449-51. Review. No abstract available 1999
52GATA2, IGF1, NFATC1
Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway.
Semsarian C, et al.
Nature 400(6744):576-81 1999
53GATA2, IGF1, NFATC1
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.
Musaro A, McCullagh KJ, Naya FJ, Olson EN, Rosenthal N.
Nature 400(6744):581-5. 1999
54IGF1
Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-I) identifies differential binding epitopes for IGFBP-1 and IGFBP-3.
Dubaquié Y, Lowman HB.
Biochemistry. 38(20):6386-96. 1999
55IGF1
Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.
Wong MS, Fong CC, Yang M.
Biochim Biophys Acta. 1432(2):293-301 1999
56IGF1
Insulin-like growth factor-I and cognitive function in healthy older men.
Aleman A, Verhaar HJ, De Haan EH, De Vries WR, Samson MM, Drent ML, Van der Veen EA, Koppeschaar HP.
J. Clin. Endocr. Metab. 84: 471-475 1999
57IGF1
Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.
Burren CP, Wilson EM, Hwa V, Oh Y, Rosenfeld RG.
J Clin Endocrinol Metab. 84(3):1096-103. 1999
58AKT1, AKT2, IGF1, IGF1R
Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I.
Kulik G, et al.
Mol Cell Biol 18(11):6711-8. 1998
59IGF1
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
Twigg SM, Baxter RC.
J Biol Chem. 273(11):6074-9. 1998
60IGF1
Insulin-like growth factor I gene deletion causing intrauterine growth retardation and severe short stature.
Woods KA, Camacho-Hubner C, Barter D, Clark AJ, Savage MO.
Acta Paediatr 423:39-45. 1997
61IGF1, IGF1D
Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.
Woods KA, Camacho-Hubner C, Savage MO, Clark AJ.
N Engl J Med 335(18):1363-7. No abstract available. 1996
62IGF1
Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.
Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG.
J Biol Chem. 271(48):30322-5. 1996
63IGF1
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.
Stewart CE, Rotwein P.
Physiol Rev. 76(4):1005-26.Click here to read 1996
64IGF1
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
Lembo G, Rockman HA, Hunter JJ, Steinmetz H, Koch WJ, Ma L, Prinz MP, Ross J Jr, Chien KR, Powell-Braxton L.
J Clin Invest. 98(11):2648-55. 1996
65IGF1
IGF-I is required for normal embryonic growth in mice.
Powell-Braxton, L.; Hollingshead, P.; Warburton, C.; Dowd, M.; Pitts-Meek, S.; Dalton, D.; Gillett, N.; Stewart, T. A.
Genes Dev 7: 2609-2617 1993
66IGF1, GHTF
Autocrine role of insulin-like growth factor (IGF)-I in a human thyroid cancer cell line.
Onoda N, et al.
Eur J Cancer 28A : 1904-1909. 1992
67IGF1
Structure and expression of the human insulin-like growth factor genes.
Sussenbach JS, Steenbergh PH, Holthuizen P.
Growth Regul. 2(1):1-9 1992
68IGF1
Dinucleotide repeat polymorphism at the human gene for insulin-like growth factor I (IGFI).
Polymeropoulos MH, et al.
Nucleic Acids Res 19 : 5797. 1991
69APOA2, APOC2, IGF1, SST, ARRP1
Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction.
Lawler M, et al.
Blood 77 : 2504-2514. 1991
70IGF1
Polymorphism and mapping of the IGF1 gene, and absence of association with stature among African Pygmies.
Bowcock A, et al.
Hum Genet 85 : 349-354. 1990
71IGF1, D19S47, D19S48, D19S49
Polymorphisms based on length variations in blocks of (dC-dA)n.(dG-dT)n repeats.
Weber JL, et al.
(HGM10) Cytogenet Cell Genet 51 : 1103-1104. 1989
72IGF1
EcoRV RFLP at the insulin-like growth factor I (IGF I) locus on chromosome 12.
Schneid H, et al.
Nucleic Acids Res 16 : 9059. 1988
73EGF, IGF1, IGF2
Human genes for insulin-like growth factors I and II and epidermal growth factor are located on 12q22-q24.1, 11p15, and 4q25-q27, respectively.
Morton CC, et al.
Cytogenet Cell Genet 41 : 245-249. 1986
74IGF1
The human gene encoding insulin-like growth factor I is located on chromosome 12.
Hšppener JWM, et al.
Hum Genet 69 : 157-160. 1985
75IGF1, IGF2
The insulin-like growth factor-1 (IGF1) is encoded at 12q22-q24.1, and insulin-like growth factor-2 (IGF2) is at 11p15.
Morton C, et al.
(HGM8) Cytogenet Cell Genet 40 : 703. 1985
76IGF1, IGF2
Sub-regional localization of human genes for insulin-like growth factors (IGF1) and II (IGF2) by in situ hybridization.
Yang-Feng TL, et al.
(HGM8) Cytogenet Cell Genet 40 : 782. 1985