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FLASH GENE
Symbol SLC7A3 contributors: mct - updated : 14-01-2016
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
HGNC id 11061
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc7a3
Homologene
FAMILY
  • solute carrier family 7
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
  • may also function as an ecotropic retroviral leukemia receptor
  • SLC7A1, SLC7A3 mediate influences of NMDA receptor activation on the MTOR pathway that regulates neuronal processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism spectrum disorders
    Variant & Polymorphism other hypomorphic variants of SLC7A3 in males with autism spectrum disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS