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FLASH GENE
Symbol SLC7A3 contributors: mct - updated : 14-01-2016
HGNC name solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
HGNC id 11061
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2265 - 619 - 2006 16332251
12 - 2289 - 619 - 2006 16332251
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus     Homo sapiens
Nervous      Homo sapiens
 brainbasal nucleicaudate nucleus   Homo sapiens
 braindiencephalonhypothalamus   Homo sapiens
 braindiencephalonthalamus   Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc7a3
Homologene
FAMILY
  • solute carrier family 7
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
  • may also function as an ecotropic retroviral leukemia receptor
  • SLC7A1, SLC7A3 mediate influences of NMDA receptor activation on the MTOR pathway that regulates neuronal processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autism spectrum disorders
    Variant & Polymorphism other hypomorphic variants of SLC7A3 in males with autism spectrum disorders
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS