| basic FUNCTION
| TP53-controled small ribonucleotide reductase, catalyzing the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides |
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direct interaction of TP53 with RRM2 and the nuclear accumulation of ribonucleotide reductase subunits after UV exposure might play a pivotal role in DNA repair |
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play essential roles in DNA repair, mtDNA synthesis, and protection against oxidative stress  |
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play key roles in forming ribonucleotide reductase holoenzyme and supplying nucleotide precursors for DNA replication and repair |
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may play a key role in defending oxidative stress by scavenging ROS, and this antioxidant property is also important for its enzymatic activity |
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plays critical roles not only in DNA damage repair but also in proliferation of cancer cells |
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required for mitochondrial DNA replication and DNA repair in quiescent cells |
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in postmitotic mammalian cells, RRM2B substitutes for protein R2 as a subunit of ribonucleotide reductase |
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its activity is required for the stability of the mt genome in differentiated tissues, shifting the attention from DNA repair to mtDNA maintenance |
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DNA damage-inducible small subunit of ribonucleotide reductase, the rate-limiting enzyme in de novo deoxyribonucleoside triphosphate synthesis |
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plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis |
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its activity is a prosurvival function inactivated by proteolysis during apoptosis |
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critical ribonucleotide reductase (RR) subunit that exists as TP53-inducible and TP53-dependent molecule |
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critical role of RRM2B in mitochondrial homeostasis and the inflammation signaling pathway in a TP53-independent manner |
