Citations for
RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress.
Cho EC, Kuo ML, Cheng JH, Cheng YC, Hsieh YC, Liu YR, Hsieh RH, Yen Y.
Mediators Inflamm 2015:287345. doi: 10.1155/2015/287345. Epub 2015 May 18. 2015
2E2F1, RRM2B
E2F1 regulates p53R2 gene expression in p53-deficient cells.
Qi JJ, Liu L, Cao JX, An GS, Li SY, Li G, Jia HT, Ni JH.
Mol Cell Biochem 399(1-2):179-88. doi: 10.1007/s11010-014-2244-7. Epub 2014 Oct 14. 2015
Caspase-dependent Proteolysis of Human Ribonucleotide Reductase Small Subunits R2 and p53R2 during Apoptosis.
Tebbi A, Guittet O, Tuphile K, Cabriť A, Lepoivre M.
J Biol Chem 290(22):14077-90. doi: 10.1074/jbc.M115.649640. Epub 2015 Apr 15. 2015
Peripheral neuropathy predicts nuclear gene defect in patients with mitochondrial ophthalmoplegia.
Horga A, Pitceathly RD, Blake JC, Woodward CE, Zapater P, Fratter C, Mudanohwo EE, Plant GT, Houlden H, Sweeney MG, Hanna MG, Reilly MM.
Brain 137(Pt 12):3200-12. doi: 10.1093/brain/awu279. Epub 2014 Oct 3. 2014
Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients.
Cho EC, Kuo ML, Liu X, Yang L, Hsieh YC, Wang J, Cheng Y, Yen Y.
Oncotarget 5(13):4834-44. 2014
Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms.
Chang L, Guo R, Huang Q, Yen Y.
Cell Rep 3(5):1389-97. doi: 10.1016/j.celrep.2013.03.040. Epub 2013 May 2. 2013
MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2.
Piao C, Youn CK, Jin M, Yoon SP, Chang IY, Lee JH, You HJ.
Cell Cycle 11(17):3237-49. doi: 10.4161/cc.21591. Epub 2012 Aug 16. 2012
Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells.
Pontarin G, Ferraro P, Bee L, Reichard P, Bianchi V.
Proc Natl Acad Sci U S A 109(33):13302-7. doi: 10.1073/pnas.1211289109. Epub 2012 Jul 30. 2012
RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.
Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y.
Sci Rep 2:822. doi: 10.1038/srep00822. Epub 2012 Nov 8. 2012
RRM2B mutations are frequent in familial PEO with multiple mtDNA deletions.
Fratter C, Raman P, Alston CL, Blakely EL, Craig K, Smith C, Evans J, Seller A, Czermin B, Hanna MG, Poulton J, Brierley C, Staunton TG, Turnpenny PD, Schaefer AM, Chinnery PF, Horvath R, Turnbull DM, Gorman GS, Taylor RW.
Neurology 76(23):2032-4. No abstract available. 2011
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells.
Wang X, Liu X, Xue L, Zhang K, Kuo ML, Hu S, Zhou B, Ann D, Zhang S, Yen Y.
Biochem Biophys Res Commun 410(1):102-7. doi: 10.1016/j.bbrc.2011.05.114. Epub 2011 May 25. 2011
p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest.
Zhang K, Wu J, Wu X, Wang X, Wang Y, Zhou N, Kuo ML, Liu X, Zhou B, Chang L, Ann D, Yen Y.
Mol Cancer Ther 10(2):269-78. doi: 10.1158/1535-7163.MCT-10-0728. Epub 2011 Jan 7. 2011
A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.
Tyynismaa H, Ylikallio E, Patel M, Molnar MJ, Haller RG, Suomalainen A.
Am J Hum Genet 85(2):290-5. Epub 2009 Aug 6. 2009
A novel mutation of the RRM2B gene in an infant with early fatal encephalomyopathy, central hypomyelination, and tubulopathy.
Acham-Roschitz B, Plecko B, Lindbichler F, Bittner R, Mache CJ, Sperl W, Mayr JA.
Mol Genet Metab 98(3):300-4. Epub 2009 Jun 25.PMID: 19616983 2009
2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase
Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y.
Biochemistry 48(46):11134-41.PMID: 19728742 2009
Regulation of p53R2 and its role as potential target for cancer therapy.
Wang X, Zhenchuk A, Wiman KG, Albertioni F.
Cancer Lett 276(1):1-7. Epub 2008 Aug 29. Review.PMID: 18760875 2009
Redox property of ribonucleotide reductase small subunit M2 and p53R2.
Liu X, Xue L, Yen Y.
Methods Mol Biol 477:195-206.PMID: 19082948 2008
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage.
Chang L, Zhou B, Hu S, Guo R, Liu X, Jones SN, Yen Y.
Proc Natl Acad Sci U S A 105(47):18519-24. Epub 2008 Nov 17.PMID: 19015526 2008
Mitochondrial DNA depletion syndrome due to mutations in the RRM2B gene.
Bornstein B, Area E, Flanigan KM, Ganesh J, Jayakar P, Swoboda KJ, Coku J, Naini A, Shanske S, Tanji K, Hirano M, DiMauro S.
Neuromuscul Disord 18(6):453-9. Epub 2008 May 27.PMID: 18504129 2008
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.
Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chretien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rotig A.
Nat Genet 39(6):776-80. Epub 2007 May 7. 2007
Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma.
Okumura H, Natsugoe S, Yokomakura N, Kita Y, Matsumoto M, Uchikado Y, Setoyama T, Owaki T, Ishigami S, Aikou T.
Clin Cancer Res 12(12):3740-5. 2006
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits.
Qiu W, Zhou B, Darwish D, Shao J, Yen Y.
Biochem Biophys Res Commun 340(2):428-34. Epub 2005 Dec 15. 2006
23TP53, RRM1, RRM2, RRM2B
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y.
Cancer Res 63(5):980-6. 2003
A ribonucleotide reductase gene involved in a p53-dependent cell-cyclecheckpoint for DNA damage.
Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, TakeiY, Nakamura Y.
Nature 404(6773):42-9. 2000