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FLASH GENE

Symbol

RARRES2

contributors: mct/npt - updated : 12-07-2017

HGNC name	retinoic acid receptor responder (tazarotene induced) 2
HGNC id	9868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the adipose depots of obese compared with lean animals and was markedly elevated during differentiation of fibroblasts into mature adipocytes (Bozaoglu 2010) constitutional     --over   in obese subjects tumoral     --low   in multiple cancer types constitutional     --over   serum RARRES2 concentrations were significantly higher in atrial fibrillation patients compared with healthy controls constitutional     --over   circulating chemerin was increased in overweight compared with normal weight polycystic ovary syndrome (PCOS) patients constitutional     --over   circulating levels of the RARRES2 are elevated in Lipodystrophy (LD), as well as independently and positively associated with HbA1c and CRP

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	serum RARRES2 may be used as a novel prognostic marker for adrenocortical carcinoma (ACC)
	is a novel biomarker of dilated cardiomyopathy
	may play a role as predictive biomarker for pre-eclampsia and be an important causative factor in the pathogenesis of pre-eclampsia
Therapy target

ANIMAL & CELL MODELS