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FLASH GENE

Symbol

PTGDR

contributors: mct - updated : 20-02-2012

HGNC name	prostaglandin D2 receptor (DP)
HGNC id	9591

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       lowly   liver       lowly Nervous brain       lowly Reproductive female system uterus     lowly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic eosinophil Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Ptgdr (74.1 pc)

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nucleus
text	multi-pass membrane protein

basic FUNCTION	acting as a receptor for prostaglandin D2 (PGD2)
	being also a thromboxane receptor
	in addition to PTDGR2, PTDGR plays an important role in eosinophil trafficking, and comediate with PTGDR2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for D-type prostanoid antagonists in the treatment of allergic disease
	PTGDR and PTGDR2, act in concert to promote a number of biological effects associated with the development and maintenance of the allergic response
	may have suppressive effects in controlling MUC5B overproduction in the airway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	male sex determination

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	prostaglandin D2 induces HMOX1 mRNA expression through the PTGDR
	balance between PTGDR and PTGDR2 could influence the degree of PGD2-induced eosinophil migration and PTGDR agonist might regulate eosinophil activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to asthma-related traits type 1 (ASRT1)

Variant & Polymorphism SNP	-613C > T PTGDR polymorphism protecting against asthma

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS