basic FUNCTION
| involved in the maintenance of the self-renewal of embryonis stem (ES) cells by suppression of gene expression |
|
may be involved in epigenetic control of gene expression in undifferentiated ES cells |
|
critical role for PRDM14 in programming PGCs and promoting pluripotency in ES cells |
|
PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET1, TET2- base excision repair (BER) cycle, resulting in the promotion of active DNA demethylation in ESCs |
|
is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation |
|
exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation |
|
might have the histone methyltransferase activity, and suppress the differentiation marker genes via histone modifications |
|
transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers |
|
HSP90AA1 and HSPA5 interact with PRDM14 and participate in cancer regulation |
|
HOXA1 displays an unexpectedly long half-life and PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1 |
|
is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency |
|
maintains stemness in embryonic stem cells and primordial germ cells via epigenetic mechanisms |
|
confers stem cell-like characteristics upon cancer cells, such as sphere formation, dye efflux, chemotherapy resistance, proliferation, and distant metastasis |