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FLASH GENE
Symbol PRDM14 contributors: mct/npt - updated : 02-10-2018
HGNC name PR domain containing 14
HGNC id 14001
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2344 64.1 571 - 2018 29178343
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx    
Reproductivefemale systemovary   
 male systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PR domain (PRDI-BF1 and RIZ) related to the SET methyltransferase domain and zinc finger motifs
  • six zinc finger DNA binding motifs, C2H2 type
  • a subtype of the SET domain which catalyzes histone methylation
  • HOMOLOGY
    Homologene
    FAMILY
  • PR-domain protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the maintenance of the self-renewal of embryonis stem (ES) cells by suppression of gene expression
  • may be involved in epigenetic control of gene expression in undifferentiated ES cells
  • critical role for PRDM14 in programming PGCs and promoting pluripotency in ES cells
  • PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET1, TET2- base excision repair (BER) cycle, resulting in the promotion of active DNA demethylation in ESCs
  • is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation
  • exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation
  • might have the histone methyltransferase activity, and suppress the differentiation marker genes via histone modifications
  • transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers
  • HSP90AA1 and HSPA5 interact with PRDM14 and participate in cancer regulation
  • HOXA1 displays an unexpectedly long half-life and PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1
  • is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency
  • maintains stemness in embryonic stem cells and primordial germ cells via epigenetic mechanisms
  • confers stem cell-like characteristics upon cancer cells, such as sphere formation, dye efflux, chemotherapy resistance, proliferation, and distant metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • regulates the proper splicing of transcripts encoding for pluripotency regulators such as POU5F1, PRDM14, E4F1 and MED24
  • maintains pluripotency of embryonic stem cells through TET1, TET2-mediated active DNA demethylation
  • its repressive function is mediated through an ETO-family co-repressor CBFA2T2, which tightly binds to the pre-SET/SET domains of PRDM14
  • PRDM14 is an interactor of HOXA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer (Nishikawa 2007)
    tumoral     --over  
    in pancreatic cancer tissues compared with normal pancreatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for predicting unfavorable prognosis in non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential therapeutic molecular target for tumor treatment
    cancerendocrinepancreas
    targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis
    ANIMAL & CELL MODELS