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FLASH GENE
Symbol HK1 contributors: mct/npt - updated : 22-12-2020
HGNC name hexokinase 1
HGNC id 4922
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • regulatory region including a mitochondrial porin-binding domain at the N terminal, protein domain responsible for binding to the outer mitochondrial membrane, and regulation of energy production and apoptosis (Hantke 2009)
  • a catalytic half carboxy-terminal
    • HOMOLOGY
    interspecies homolog to rattus Hk1
    Homologene
    FAMILY
  • hexokinase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • key enzymes of glycolysis that catalyzes the phosphorylation of glucose to glucose-6-phosphate (de Vooght 2009)
  • may influence A1C levels through its anemic effect or its effect on glucose metabolism in red blood cells (Bonnefond 2009)
  • is ubiquitylated by PRKN upon dissipation of mitochondrial membrane potential
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding HDAC1, in the outer mitochondrial membrane (VDAC1-based peptides interfering with HK-mediated anti-apoptotic activity may potentiate the efficacy of conventional chemotherapeutic agents)(Arzoine 2009)
  • mitochondrial hexokinase I (HK1) is a novel PRKN substrate
  • PRKN-mediated HK1 degradation may inhibit glycolysis, and consequently Parkin’s mitochondriallocalization is hindered, suggesting HK1 functions as a negative feedback component
  • in the presence of Ca2+, KCNIP3 interacts with HK1, a protein known to bind mitochondria and regulate apoptosis
  • FUBP1 upregulates the mRNA levels of two hexokinase genes, HK1 and HK2
  • direct, GTP-dependent interaction between KRAS and hexokinase 1 (HK1) that alters the activity of the kinase, and thereby establish that HK1 is an effector of KRAS
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HK1 , HMSNR , RP79 , NEDVIBA
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    reduced erythroid transcription of HK1 together with aberrant splicing of both HK1 and red cell specific-hexokinase results in hexokinase deficiency and mild chronic hemolysis (de Vooght 2009)
    Susceptibility to variation of glycated hemoglobin levels in a non-diabetic population
    Variant & Polymorphism other association between glycated hemoglobin levels and HK1 polymorphisms (Pare 2008)
    Candidate gene
    Marker
  • overexpression of HK1 may act as a significant biomarker of poor prognosis for patients with colorectal cancer
    • Therapy target
    ANIMAL & CELL MODELS