| 1 | HK1, NEDVIBA
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| De novo variants in HK1 associated with neurodevelopmental abnormalities and visual impairment.
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| Okur V, Cho MT, van Wijk R, van Oirschot B, Picker J, Coury SA, Grange D, Manwaring L, Krantz I, Muraresku CC, Hulick PJ, May H, Pierce E, Place E, Bujakowska K, Telegrafi A, Douglas G, Monaghan KG, Begtrup A, Wilson A, Retterer K, Anyane-Yeboa K, Chung WK.
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| Eur J Hum Genet. Jul;27(7):1081-1089. doi: 10.1038/s41431-019-0366-9. Epub 2019 Feb 18. 2019
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| 2 | FUBP1, HK1, HK2
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| Fubp1 supports the lactate-Akt-mTOR axis through the upregulation of Hk1 and Hk2.
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| Kang M, Lee SM, Kim W, Lee KH, Kim DY.
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| Biochem Biophys Res Commun. Apr 23;512(1):93-99. doi: 10.1016/j.bbrc.2019.03.005. Epub 2019 Mar 11 2019
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| 3 | HK1, KRAS
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| KRAS4A directly regulates hexokinase 1.
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| Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR.
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| Nature Dec;576(7787):482-486. doi: 10.1038/s41586-019-1832-9. Epub 2019 Dec 11. 2019
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| 4 | HK1, RP79
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| The phenotypic variability of HK1-associated retinal dystrophy
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| Yuan Z, Li B, Xu M, Chang EY, Li H, Yang L, Wu S, Soens ZT, Li Y, Wong LC, Lewis RA, Sui R, Chen R.
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| Sci Rep. Aug 1;7(1):7051. doi: 10.1038/s41598-017-07629-3. 2017
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| 5 | HK1, HK1D
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| Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1.
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| Koralkova P, Mojzikova R, van Oirschot B, Macartney C, Timr P, Vives Corrons JL, Striezencova Laluhova Z, Lejhancova K, Divoky V, van Wijk R.
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| Blood Cells Mol Dis. Jul;59:71-6. doi: 10.1016/j.bcmd.2016.04.002. Epub 2016 Apr 22 2016
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| 6 | HK1
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| Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.
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| He X, Lin X, Cai M, Zheng X, Lian L, Fan D, Wu X, Lan P, Wang J.
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| Tumour Biol. Mar;37(3):3887-95. doi: 10.1007/s13277-015-4255-8. Epub 2015 Oct 17 2016
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| 7 | HK1, RP79
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| A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa.
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| Wang F, Wang Y, Zhang B, Zhao L, Lyubasyuk V, Wang K, Xu M, Li Y, Wu F, Wen C, Bernstein PS, Lin D, Zhu S, Wang H, Zhang K, Chen R.
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| Invest Ophthalmol Vis Sci. Oct 14;55(11):7159-64. doi: 10.1167/iovs.14-15520 2014
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| 8 | HK1, KCNIP3
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| The regulation of apoptosis by the downstream regulatory element antagonist modulator/potassium channel interacting protein 3 (DREAM/KChIP3) through interactions with hexokinase I.
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| Craig TA, Ramachandran PL, Bergen HR 3rd, Podratz JL, Windebank AJ, Kumar R.
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| Biochem Biophys Res Commun 433(4):508-12. doi: 10.1016/j.bbrc.2013.03.016. Epub 2013 Mar 21.
2013
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| 9 | HK1, PRKN
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| Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase.
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| Okatsu K, Iemura S, Koyano F, Go E, Kimura M, Natsume T, Tanaka K, Matsuda N.
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| Biochem Biophys Res Commun 428(1):197-202. doi: 10.1016/j.bbrc.2012.10.041. Epub 2012 Oct 13.
2012
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| 10 | HK1, HMSNR
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| A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR).
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| Hantke J, Chandler D, King R, Wanders RJ, Angelicheva D, Tournev I, McNamara E, Kwa M, Guergueltcheva V, Kaneva R, Baas F, Kalaydjieva L.
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| Eur J Hum Genet 17(12):1606-14. Epub 2009 Jun 17.PMID: 19536174 2009
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| 11 | HK1, HK1D
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| First mutation in the red blood cell-specific promoter of hexokinase combined with a novel missense mutation causes hexokinase deficiency and mild chronic hemolysis.
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| de Vooght KM, van Solinge WW, van Wesel AC, Kersting S, van Wijk R.
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| Haematologica 94(9):1203-10. Epub 2009 Jul 16.PMID: 19608687 2009
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| 12 | HK1
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| Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
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| Bonnefond A, Vaxillaire M, Labrune Y, Lecoeur C, Chèvre JC, Bouatia-Naji N, Cauchi S, Balkau B, Marre M, Tichet J, Riveline JP, Hadjadj S, Gallois Y, Czernichow S, Hercberg S, Kaakinen M, Wiesner S, Charpentier G, Lévy-Marchal C, Elliott P, Jarvelin MR, Horber F, Dina C, Pedersen O, Sladek R, Meyre D, Froguel P.
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| Diabetes 58(11):2687-97. Epub 2009 Aug 3.PMID: 19651813 2009
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| 13 | HK1, HK2, VDAC1
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| Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
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| Arzoine L, Zilberberg N, Ben-Romano R, Shoshan-Barmatz V.
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| J Biol Chem 284(6):3946-55. Epub 2008 Dec 2.PMID: 19049977 2009
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| 14 | HK1, HK2
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| Enzymatic properties of the N- and C-terminal halves of human hexokinase II.
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| Ahn KJ, Kim J, Yun M, Park JH, Lee JD.
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| BMB Rep 42(6):350-5.PMID: 19558793 2009
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| 15 | HK1
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| Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
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| Paré G, Chasman DI, Parker AN, Nathan DM, Miletich JP, Zee RY, Ridker PM.
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| PLoS Genet 4(12):e1000312. Epub 2008 Dec 19.PMID: 19096518 2008
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| 16 | HK1, VDAC1
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| Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.
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| Abu-Hamad S, Zaid H, Israelson A, Nahon E, Shoshan-Barmatz V.
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| J Biol Chem 283(19):13482-90. Epub 2008 Feb 28.PMID: 18308720 2008
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| 17 | HK1
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| Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves.
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| Tsai HJ.
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| J Biomed Sci 14(2):195-202. Epub 2006 Nov 2.PMID: 17080299 2007
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| 18 | HK1
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| Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA.
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| Andreoni F, Ruzzo A, Magnani M.
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| Biochim Biophys Acta 1493(1-2):19-26. 2000
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| 19 | HK1
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| Human HKR isozyme: organization of the hexokinase I gene, the erythroid-specific promoter, and transcription initiation site.
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| Murakami K, et al.
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| Mol Genet Metab 67(2):118-30. 1999
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| 20 | HK1
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| Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region.
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| Ruzzo A, Andreoni F, Magnani M.
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| Biochem J 331 ( Pt 2):607-13. 1998
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| 21 | HK1, HK1D
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| Identification of the cDNA for human red blood cell-specific hexokinase isozyme.
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| Murakami K, et al.
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| Blood 89 : 762-766. 1997
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| 22 | HK1, HK1D
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| Hexokinase mutations that produce nonspherocytic hemolytic anemia.
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| Bianchi M, et al.
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| Blood Cells 15 : 2-8. 1995
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| 23 | HK1
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| Mapping of human hexokinase 1 gene to 10q11-qter.
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| Daniele A, et al.
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| Hum Hered 42 : 107-110. 1992
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| 24 | HK1
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| Characterization of human genomic yeast artificial chromosome inserts containing hexokinase 1 coding information on chromosome 10.
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| Gelb BD, et al.
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| Biochem Med Metab Biol 47 : 265-269. 1992
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| 25 | HK1
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| Localization of the human hexokinase I gene (HK1) to chromosome 10q22.
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| Shows TB, et al.
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| (HGM10) Cytogenet Cell Genet 51 : 1079. 1989
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| 26 | HK1
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| HincII RFLP at the human hexokinase I (HK1) locus on chromosome 10.
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| Nishi S, et al.
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| Nucleic Acids Res 17 : 7547. 1989
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| 27 | HK1
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| Human hexokinase: sequences of amino- and carbonyl-terminal halves are homologous.
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| Nishi S, et al.
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| Biochem Biophys Res Commun 157 : 937-943. 1988
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| 28 | HK1
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| Generalized hexokinase deficiency in the blood cells of a patient with nonspherocytic hemolytic anemia.
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| Rijksen G, et al.
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| Blood 61 : 12-18. 1983
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| 29 | HK1, PPA1, GOT1
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| Refined mapping of GOT1, PP, and HK1 on chromosome 10.
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| Baeteman MA, et al.
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| Cytogenet Cell Genet 32 : 251. 1982
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| 30 | HK1
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| Regional mapping of the locus for hexokinase-1 (HK1) to 10p11-q23 by gene dosage in human fibroblats.
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| Gitelman BJ, et al.
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| Hum Genet 60 : 227-229. 1982
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| 31 | HK1
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| Increased HK-1 activity levels in the red cells of a patient with a de novo trisomy 10p: t(Y;10)(p11;p12).
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| Dallapiccola B, et al.
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| Hum Genet 50 : 45-49. 1979
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| 32 | HK1
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| Localization of the structural genes for hexokinase-1 and inorganic pyrophosphatase on region (pter-q24) of human chromosome 10.
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| Chern CJ.
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| Cytogenet Cell Genet 17 : 338-342. 1976
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| 33 | HK1
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| Synteny of human genes for glutamic oxalacetic transaminase and hexokinase in somatic cell hybrids.
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| Shows TB.
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| Cytogenet Cell Genet 13 : 143-145. 1974
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| 34 | HK1
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| Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia.
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| Altay C, et al.
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| Blood 36(2):219-27. No abstract available 1970
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