Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MMP3

contributors: mct/pgu - updated : 08-02-2016

HGNC name	matrix metalloproteinase 3 (stromelysin 1, progelatinase)
HGNC id	7173

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancer in advanced stage constitutional     --low   AHSG, MMP9, and MMP3 levels were significantly lower in migraine than controls

Susceptibility

abdominal aortic aneurysm and carotid artery atherosclerosis myocardial infarction to Moyamoya disease (MMD)

Variant & Polymorphism other	polymorphism 5A/5A in non smocker and 6A/6A in smocker increasing the risk of acute myocardial infarction
	the 5A allele frequency was higher in abdominal aortic aneurysm compared with controls
	functional polymorphism in the promoter might be associated with susceptibility to MMD

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   MMP3 may serve as cellular targets for therapy against neurodegenerative diseases

ANIMAL & CELL MODELS