| basic FUNCTION
| regulator of matrix remodeling |
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activates a number of pro-MMPs |
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critical role for the generation of the fully active MMP1 |
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involved in cell migration, mammary epithelial cell apoptosis and alveolar formation, mammary epithelial-mesenchymal cell conversion, generation of angiostatin-like fragment |
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involved in enhanced collagen affinity, release of bFGF, increased bioavailability of IGF1, TGF beta and cell, pro/antiinflammatory roles |
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inhibiting breast tumor cell invasion by a mechanism involving plasminogen degradation to fragments that limit plasminogen activation and the degradation of laminin |
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involved in disrupted cell aggregation and increased cell invasion |
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signaling proteinase from apoptotic neuronal cells that activates microglia, and may play a major role in degenerative brain disorders, such as Parkinson's disease |
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having a function as a trans regulator of connective tissue growth factor (CTGF)  |
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plays a role in the ER stress-induced apoptosis |
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is both a direct transcriptional target and a necessa |
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involvement in digestion of SNCA in dopaminergic neurons, playing a pivotal role in the progression of Parkinson disease through modulation of SNCA in aggregation, Lewy body formation, and neurotoxicity |
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may contribute to the breakdown of articular cartilage during arthritis |
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role in the pathogenesis of idiopathic pulmonary fibrosis, through activation of beta-catenin signaling and induction of epithelial-mesenchymal transition |
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GPR65 is vital regulatory genes upstream of MMP3 |
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role for SDC4 in mediating matrix degradation in both intervertebral discs and cartilage by controlling ADAMTS5 function and MMP3 expression |
