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| Actn3 KO mice showing reductions in muscle strength, increased endurance capacity, reduced fast fiber size, shifts in fast fiber metabolism toward oxidative metabolism | |
Actn3(-/-) mouse displays significantly reduced bone mass, with reduced cortical bone volume (-14p100) and trabecular number (-61p100) seen by microCT  |
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deficiency in the Actn3 KO mouse results in a shift in fast-twitch fibres towards oxidative metabolism, which would be more "energy efficient" in famine, and beneficial to endurance performance |
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Actn3 KO mice were significantly lighter than their WT counterparts and therefore showed an improved cold tolerance after normalizing for body weight |