| basic FUNCTION
| phosphorylation of serines and threonine and having a tyrosine kinase activity |
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implicated in the control of meiosis |
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may function as a kinase early in the DNA damage response pathway |
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involved in cilium control |
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CLASP2 and NEK1 proteins are present in a centrosomal complex and participate in cell cycle and cell division mechanisms  |
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is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage |
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serine/threonine kinase with proposed function in DNA double-strand repair, neuronal development, and coordination of cell-cycle-associated ciliogenesis |
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involved early in a DNA damage sensing/repair pathway |
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functions independently of canonical DNA damage responses requiring the PI3 kinase-like proteins ATM and ATR |
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important for proper checkpoint control |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |
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ATR-associated kinase, NEK1, enhances the stability and activity of ATR–ATRIP before DNA damage, priming ATR–ATRIP for a robust DNA damage response |
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required for the phosphorylation of multiple signaling proteins along the ATR pathway, suggesting a role of NEK1 in the initiation of ATR response |
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function of NEK1 in DNA damage signaling is critical in specific tissues |
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regulate DNA damage response, centrosome duplication and primary cilium formation |
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regulatory role for NEK1 in the regulation of spindle architecture and function during meiosis |
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serves likely as a hub signalling kinase in response to DNA damage, modulating DNA repair capacity, mitochondrial activity and cell fate determination |
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FAM189B like NEK1 is required for homologous recombination |
