Citations for
1CCP110, CEP104, NEK1
The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase.
Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M.
Structure 25(1):146-156. doi: 10.1016/j.str.2016.11.014. Epub 2016 Dec 22. 2017
2NEK1, PDS5B, PPP1CC, WAPL
Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
Brieño-Enríquez MA, Moak SL, Toledo M, Filter JJ, Gray S, Barbero JL, Cohen PE, Holloway JK.
Cell Rep 17(4):977-986. doi: 10.1016/j.celrep.2016.09.059. 2016
3CFAP410, NEK1
The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P.
Acta Biochim Biophys Sin (Shanghai) 47(10):834-41. doi: 10.1093/abbs/gmv076. Epub 2015 Aug 18. 2015
4NEK1
Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.
Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ.
J Biomed Sci 21(1):63. doi: 10.1186/s12929-014-0063-5. 2014
5ATR, ATRIP, CHEK1, NEK1
Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.
Liu S, Ho CK, Ouyang J, Zou L.
Proc Natl Acad Sci U S A 110(6):2175-80. doi: 10.1073/pnas.1217781110. Epub 2013 Jan 23. 2013
6NEK1, XRCC5
Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.
Patil M, Pabla N, Ding HF, Dong Z.
Cell Cycle 12(16):2608-16. doi: 10.4161/cc.25624. Epub 2013 Jul 10. 2013
7NEK1, VHL
Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.
Patil M, Pabla N, Huang S, Dong Z.
Cell Cycle 12(1):166-71. doi: 10.4161/cc.23053. Epub 2012 Dec 19. 2013
8DYNC2H1, NEK1, SRPS2, SRPS3A
NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases.
El Hokayem J, Huber C, Couvé A, Aziza J, Baujat G, Bouvier R, Cavalcanti DP, Collins FA, Cordier MP, Delezoide AL, Gonzales M, Johnson D, Le Merrer M, Levy-Mozziconacci A, Loget P, Martin-Coignard D, Martinovic J, Mortier GR, Perez MJ, Roume J, Scarano G, Munnich A, Cormier-Daire V.
J Med Genet 49(4):227-33. 2012
9NEK1, NEK10, NEK11, NEK2, NEK6, NEK7, NEK9
Cell cycle regulation by the NEK family of protein kinases.
Fry AM, O'Regan L, Sabir SR, Bayliss R.
J Cell Sci 125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review. 2012
10NEK1, SRPS2
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stöss H, Beinder E, Abou Jamra R, Ekici AB, Schröder-Kress N, Aigner T, Kirchner T, Reis A, Brandstätter JH, Rauch A.
Am J Hum Genet 88(1):106-14.PMID: 21211617 2011
11NEK1
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL.
Cell Cycle 10(4):655-63. Epub 2011 Feb 15. 2011
12NEK1, PKD2, WWTR1
Nek1 and TAZ interact to maintain normal levels of polycystin 2.
Yim H, Sung CK, You J, Tian Y, Benjamin T.
J Am Soc Nephrol 22(5):832-7. doi: 10.1681/ASN.2010090992. Epub 2011 Apr 7. 2011
13NEK1, SRPS2
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stöss H, Beinder E, Abou Jamra R, Ekici AB, Schröder-Kress N, Aigner T, Kirchner T, Reis A, Brandstätter JH, Rauch A.
Am J Hum Genet 88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004. 2011
14FKBP6, NEK1
NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis.
Holloway K, Roberson EC, Corbett KL, Kolas NK, Nieves E, Cohen PE.
Genes (Basel) 2(1):260-79. doi: 10.3390/genes2010260. 2011
15NEK1
Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.
Pelegrini AL, Moura DJ, Brenner BL, Ledur PF, Maques GP, Henriques JA, Saffi J, Lenz G.
Mutagenesis 25(5):447-54. doi: 10.1093/mutage/geq026. Epub 2010 May 25. 2010
16CLASP2, FEZ1, NEK1
FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
Lanza DC, Meirelles GV, Alborghetti MR, Abrile CH, Lenz G, Kobarg J.
Mol Cell Biochem 338(1-2):35-45. doi: 10.1007/s11010-009-0317-9. Epub 2009 Nov 19. 2010
17NEK1
The NIMA-related kinase NEK1 cycles through the nucleus.
Hilton LK, White MC, Quarmby LM.
Biochem Biophys Res Commun 389(1):52-6. doi: 10.1016/j.bbrc.2009.08.086. Epub 2009 Aug 21. 2009
18NEK1, VDAC1
Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1.
Chen Y, Craigen WJ, Riley DJ.
Cell Cycle 8(2):257-67. Epub 2009 Jan 4. 2009
19NEK1
The mammalian Nek1 kinase is involved in primary cilium formation.
Shalom O, Shalva N, Altschuler Y, Motro B.
FEBS Lett 582(10):1465-70. Epub 2008 Apr 1. 2008
20NEK1, NEK11, NEK2, NEK6, NEK7, NEK9
Mitotic regulation by NIMA-related kinases.
O'regan L, Blot J, Fry AM.
Cell Div 2:25.PMID: 17727698 2007
21NEK1
NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
Polci R, Peng A, Chen PL, Riley DJ, Chen Y.
Cancer Res 64(24):8800-3. 2004
22NDC80, NEK1
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH.
J Biol Chem 277(51):49408-16. Epub 2002 Oct 16. 2002
23BTBD9, CCDC85A, CSMD2, CSMD3, FAM111A, FAM65A, FMNL2, GALNT13, GPRIN1, KIAA1919, KLHL32, LENG8, MIS18BP1, NEK1, PKD1L2, PNMA5, RHPN1, SCIN, SSFA2, SYNGAP1, TMEM200A, TUBGCP5, VARS2, WDR40A, ZNF45
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.
Nagase T, Kikuno R, Ohara O.
DNA Res 8(4):179-87. 2001
24NEK1
Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.
Upadhya P, Birkenmeier EH, Birkenmeier CS, Barker JE.
Proc Natl Acad Sci U S A 97(1):217-21. 2000
25NEK1
Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease.
Vogler C, Homan S, Pung A, Thorpe C, Barker J, Birkenmeier EH, Upadhya P.
J Am Soc Nephrol 10(12):2534-9. 1999
26ANKRD13A, C14orf131, CACTIN, CCDC34, CEP83, KCTD3, KIF21A, MED6, NEK1, PHF11, PPP2R3B, PPP2R3BY, QTLIGES1, RBM5, RNF12, USP32, YTHDF2, YTHDF2P, ZC3H14, ZKSCAN1, ZNF608
Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ.
Int J Cancer 83(4):456-64. 1999
27NEK1, NEK2, NEK3, NEK4
NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
Chen A, Yanai A, Arama E, Kilfin G, Motro B.
Gene 234(1):127-37. 1999
28NEK1
Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8.
Janaswami PM, Birkenmeier EH, Cook SA, Rowe LB, Bronson RT, Davisson MT.
Genomics 40(1):101-7. 1997
29NEK1
A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.
Letwin K, Mizzen L, Motro B, Ben-David Y, Bernstein A, Pawson T.
EMBO J 11(10):3521-31. 1992