| 1 | ENTREP3, NEK1
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| Functional characterization of C21ORF2 association with the NEK1 kinase mutated in human in diseases.
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| Gregorczyk M, Pastore G, Muñoz I, Carroll T, Streubel J, Munro M, Lis P, Lange S, Lamoliatte F, Macartney T, Toth R, Brown F, Hastie J, Pereira G, Durocher D, Rouse J.
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| Life Sci Alliance. May 15;6(7):e202201740. doi: 10.26508/lsa.202201740 2023
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| 2 | ALS24, NEK1
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| Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.
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| Mann JR, McKenna ED, Mawrie D, Papakis V, Alessandrini F, Anderson EN, Mayers R, Ball HE, Kaspi E, Lubinski K, Baron DM, Tellez L, Landers JE, Pandey UB, Kiskinis E.
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| Sci Adv. Aug 18;9(33):eadi5548. doi: 10.1126/sciadv.adi5548. Epub 2023 Aug 16 2023
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| 3 | NEK1
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| NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation.
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| Wang H, Qi W, Zou C, Xie Z, Zhang M, Naito MG, Mifflin L, Liu Z, Najafov A, Pan H, Shan B, Li Y, Zhu ZJ, Yuan J.
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| Nat Commun. Aug 10;12(1):4826. doi: 10.1038/s41467-021-25157-7. 2021
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| 4 | ALS24, NEK1
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| NEK1 mutations and the risk of amyotrophic lateral sclerosis (ALS): a meta-analysis.
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| Yao L, He X, Cui B, Zhao F, Zhou C.
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| Neurol Sci. Apr;42(4):1277-1285. doi: 10.1007/s10072-020-05037-6. Epub 2021 Jan 18. 2021
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| 5 | NEK1
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| NEK1 deficiency affects mitochondrial functions and the transcriptome of key DNA repair pathways.
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| Martins MB, Perez AM, Bohr VA, Wilson DM 3rd, Kobarg J.
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| Mutagenesis. Jul 7;36(3):223-236. doi: 10.1093/mutage/geab011. 2021
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| 6 | NEK1, YAP1
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| NEK1 Phosphorylation of YAP Promotes Its Stabilization and Transcriptional Output.
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| Khalil MI, Ghosh I, Singh V, Chen J, Zhu H, De Benedetti A.
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| Cancers (Basel) Dec 7;12(12):3666. doi: 10.3390/cancers12123666 2020
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| 7 | ALS24, NEK1
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| NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons.
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| Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Speit G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM.
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| Stem Cell Res. Jul;30:150-162. doi: 10.1016/j.scr.2018.06.005. Epub 2018 Jun 12 2018
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| 8 | CCP110, CEP104, NEK1
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| The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase.
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| Al-Jassar C, Andreeva A, Barnabas DD, McLaughlin SH, Johnson CM, Yu M, van Breugel M.
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| Structure 25(1):146-156. doi: 10.1016/j.str.2016.11.014. Epub 2016 Dec 22.
2017
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| 9 | NEK1
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| NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X
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| Brieño-Enríquez MA, Moak SL, Holloway JK, Cohen PE.
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| PLoS One. Oct 5;12(10):e0185780. doi: 10.1371/journal.pone.0185780 2017
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| 10 | NEK1, SRPS2
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| Axial spondylometaphyseal dysplasia is also caused by NEK1 mutations.
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| Wang Z, Horemuzova E, Iida A, Guo L, Liu Y, Matsumoto N, Nishimura G, Nordgren A, Miyake N, Tham E, Grigelioniene G, Ikegawa S.
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| J Hum Genet. Apr;62(4):503-506. doi: 10.1038/jhg.2016.157. Epub 2017 Jan 26. 2017
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| 11 | NEK1, PDS5B, PPP1CC, WAPL
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| Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
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| Brieño-Enríquez MA, Moak SL, Toledo M, Filter JJ, Gray S, Barbero JL, Cohen PE, Holloway JK.
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| Cell Rep 17(4):977-986. doi: 10.1016/j.celrep.2016.09.059.
2016
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| 12 | NEK1, RAD51
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| Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.
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| Spies J, Waizenegger A, Barton O, Sürder M, Wright WD, Heyer WD, Löbrich M.
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| Mol Cell. Jun 16;62(6):903-917. doi: 10.1016/j.molcel.2016.04.032. Epub 2016 Jun 2. 2016
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| 13 | CFAP410, NEK1
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| The NEK1 interactor, C21ORF2, is required for efficient DNA damage repair.
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| Fang X, Lin H, Wang X, Zuo Q, Qin J, Zhang P.
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| Acta Biochim Biophys Sin (Shanghai) 47(10):834-41. doi: 10.1093/abbs/gmv076. Epub 2015 Aug 18.
2015
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| 14 | NEK1
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| Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.
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| Chen Y, Chiang HC, Litchfield P, Pena M, Juang C, Riley DJ.
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| J Biomed Sci 21(1):63. doi: 10.1186/s12929-014-0063-5.
2014
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| 15 | ATR, ATRIP, CHEK1, NEK1
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| Nek1 kinase associates with ATR-ATRIP and primes ATR for efficient DNA damage signaling.
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| Liu S, Ho CK, Ouyang J, Zou L.
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| Proc Natl Acad Sci U S A 110(6):2175-80. doi: 10.1073/pnas.1217781110. Epub 2013 Jan 23.
2013
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| 16 | NEK1, XRCC5
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| Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.
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| Patil M, Pabla N, Ding HF, Dong Z.
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| Cell Cycle 12(16):2608-16. doi: 10.4161/cc.25624. Epub 2013 Jul 10.
2013
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| 17 | NEK1, VHL
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| Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.
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| Patil M, Pabla N, Huang S, Dong Z.
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| Cell Cycle 12(1):166-71. doi: 10.4161/cc.23053. Epub 2012 Dec 19.
2013
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| 18 | DYNC2H1, NEK1, SRPS2, SRPS3A
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| NEK1 and DYNC2H1 are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases.
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| El Hokayem J, Huber C, Couvé A, Aziza J, Baujat G, Bouvier R, Cavalcanti DP, Collins FA, Cordier MP, Delezoide AL, Gonzales M, Johnson D, Le Merrer M, Levy-Mozziconacci A, Loget P, Martin-Coignard D, Martinovic J, Mortier GR, Perez MJ, Roume J, Scarano G, Munnich A, Cormier-Daire V.
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| J Med Genet 49(4):227-33. 2012
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| 19 | NEK1, NEK10, NEK11, NEK2, NEK6, NEK7, NEK9
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| Cell cycle regulation by the NEK family of protein kinases.
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| Fry AM, O'Regan L, Sabir SR, Bayliss R.
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| J Cell Sci 125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review.
2012
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| 20 | NEK1, SRPS2
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| NEK1 mutations cause short-rib polydactyly syndrome type majewski.
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| Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stöss H, Beinder E, Abou Jamra R, Ekici AB, Schröder-Kress N, Aigner T, Kirchner T, Reis A, Brandstätter JH, Rauch A.
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| Am J Hum Genet 88(1):106-14.PMID: 21211617 2011
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| 21 | NEK1
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| Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
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| Chen Y, Chen CF, Riley DJ, Chen PL.
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| Cell Cycle 10(4):655-63. Epub 2011 Feb 15.
2011
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| 22 | NEK1, PKD2, WWTR1
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| Nek1 and TAZ interact to maintain normal levels of polycystin 2.
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| Yim H, Sung CK, You J, Tian Y, Benjamin T.
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| J Am Soc Nephrol 22(5):832-7. doi: 10.1681/ASN.2010090992. Epub 2011 Apr 7.
2011
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| 23 | NEK1, SRPS2
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| NEK1 mutations cause short-rib polydactyly syndrome type majewski.
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| Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stöss H, Beinder E, Abou Jamra R, Ekici AB, Schröder-Kress N, Aigner T, Kirchner T, Reis A, Brandstätter JH, Rauch A.
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| Am J Hum Genet 88(1):106-14. doi: 10.1016/j.ajhg.2010.12.004.
2011
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| 24 | FKBP6, NEK1
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| NEK1 Facilitates Cohesin Removal during Mammalian Spermatogenesis.
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| Holloway K, Roberson EC, Corbett KL, Kolas NK, Nieves E, Cohen PE.
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| Genes (Basel) 2(1):260-79. doi: 10.3390/genes2010260.
2011
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| 25 | NEK1
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| Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest.
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| Pelegrini AL, Moura DJ, Brenner BL, Ledur PF, Maques GP, Henriques JA, Saffi J, Lenz G.
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| Mutagenesis 25(5):447-54. doi: 10.1093/mutage/geq026. Epub 2010 May 25.
2010
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| 26 | CLASP2, FEZ1, NEK1
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| FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC.
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| Lanza DC, Meirelles GV, Alborghetti MR, Abrile CH, Lenz G, Kobarg J.
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| Mol Cell Biochem 338(1-2):35-45. doi: 10.1007/s11010-009-0317-9. Epub 2009 Nov 19.
2010
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| 27 | NEK1
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| The NIMA-related kinase NEK1 cycles through the nucleus.
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| Hilton LK, White MC, Quarmby LM.
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| Biochem Biophys Res Commun 389(1):52-6. doi: 10.1016/j.bbrc.2009.08.086. Epub 2009 Aug 21.
2009
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| 28 | NEK1, VDAC1
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| Nek1 regulates cell death and mitochondrial membrane permeability through phosphorylation of VDAC1.
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| Chen Y, Craigen WJ, Riley DJ.
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| Cell Cycle 8(2):257-67. Epub 2009 Jan 4.
2009
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| 29 | NEK1
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| The mammalian Nek1 kinase is involved in primary cilium formation.
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| Shalom O, Shalva N, Altschuler Y, Motro B.
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| FEBS Lett 582(10):1465-70. Epub 2008 Apr 1.
2008
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| 30 | NEK1, NEK11, NEK2, NEK6, NEK7, NEK9
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| Mitotic regulation by NIMA-related kinases.
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| O'regan L, Blot J, Fry AM.
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| Cell Div 2:25.PMID: 17727698 2007
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| 31 | NEK1
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| NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
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| Polci R, Peng A, Chen PL, Riley DJ, Chen Y.
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| Cancer Res 64(24):8800-3.
2004
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| 32 | NDC80, NEK1
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| Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
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| Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH.
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| J Biol Chem 277(51):49408-16. Epub 2002 Oct 16. 2002
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| 33 | BTBD9, CCDC85A, CSMD2, CSMD3, FAM111A, FAM65A, FMNL2, GALNT13, GPRIN1, KIAA1919, KLHL32, LENG8, MIS18BP1, NEK1, PKD1L2, PNMA5, RHPN1, SCIN, SSFA2, SYNGAP1, TMEM200A, TUBGCP5, VARS2, WDR40A, ZNF45
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| Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.
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| Nagase T, Kikuno R, Ohara O.
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| DNA Res 8(4):179-87. 2001
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| 34 | NEK1
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| Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice.
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| Upadhya P, Birkenmeier EH, Birkenmeier CS, Barker JE.
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| Proc Natl Acad Sci U S A 97(1):217-21. 2000
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| 35 | NEK1
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| Clinical and pathologic findings in two new allelic murine models of polycystic kidney disease.
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| Vogler C, Homan S, Pung A, Thorpe C, Barker J, Birkenmeier EH, Upadhya P.
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| J Am Soc Nephrol 10(12):2534-9. 1999
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| 36 | ANKRD13A, C14orf131, CACTIN, CCDC34, CEP83, KCTD3, KIF21A, MED6, NEK1, PHF11, PPP2R3B, PPP2R3BY, QTLIGES1, RBM5, RNF12, USP32, YTHDF2, YTHDF2P, ZC3H14, ZKSCAN1, ZNF608
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| Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
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| Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ.
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| Int J Cancer 83(4):456-64. 1999
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| 37 | NEK1, NEK2, NEK3, NEK4
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| NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
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| Chen A, Yanai A, Arama E, Kilfin G, Motro B.
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| Gene 234(1):127-37.
1999
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| 38 | NEK1
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| Identification and genetic mapping of a new polycystic kidney disease on mouse chromosome 8.
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| Janaswami PM, Birkenmeier EH, Cook SA, Rowe LB, Bronson RT, Davisson MT.
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| Genomics 40(1):101-7. 1997
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| 39 | NEK1
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| A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.
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| Letwin K, Mizzen L, Motro B, Ben-David Y, Bernstein A, Pawson T.
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| EMBO J 11(10):3521-31. 1992
|