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FLASH GENE

Symbol

MPZL1

contributors: mct/npt - updated : 04-07-2008

HGNC name	myelin protein zero-like 1
HGNC id	7226

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q23.3      Physical location : 167.691.186 - 167.761.155
Synonym name	myelin protein zero-like protein MPZL1b
	protein zero-related
	immunoglobulin family transmembrane protein
Synonym symbol(s)	PZR, FLJ21047, PZR1b, PZRa, PZRb, FLJ21047

DNA

TYPE	functioning gene
STRUCTURE	68.00 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - - 3795 - 209 - He (2006) variant 1 - - 3898 29.1 269 - He (2006)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive mouth       highly Endocrine neuroendocrine pituitary     highly Lymphoid/Immune spleen         Nervous brain         Reproductive female system uterus cervix   highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence
	an extracellular single immunoglobulin like domain
	two putatives sites of glycosylation
	single transmembrane segment
	two tyrosine phosphorylation sites

conjugated

GlycoP , PhosphoP

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY	immunoglobulin superfamily
	myelin P0 protein family

CATEGORY

receptor membrane tyrosine

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	play an important role in cell signaling
	may be important in the predisposition to schizophrenia
	with SIRPA have been implicated in extracellular matrix-dependent signaling
	having a potential role in adhesion-dependent signaling because it becomes inducibly tyrosyl-phosphorylated upon plating cells onto fibronectin, yet it fails to do so in response to growth factors
	might serve as an adhesion-regulated signaling molecule

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to SHP-2, cSrc, concanavalin A (Con A)

cell & other

REGULATION

activated by

phosphorylation cSrc

inhibited by

dephosphorylation SHP-2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function in schizophrenia brain tissue

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS