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FLASH GENE
Symbol MPZL1 contributors: mct/npt - updated : 04-07-2008
HGNC name myelin protein zero-like 1
HGNC id 7226
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth   highly
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivefemale systemuteruscervix highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • an extracellular single immunoglobulin like domain
  • two putatives sites of glycosylation
  • single transmembrane segment
  • two tyrosine phosphorylation sites
  • conjugated GlycoP , PhosphoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • myelin P0 protein family
  • CATEGORY receptor membrane tyrosine
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • play an important role in cell signaling
  • may be important in the predisposition to schizophrenia
  • with SIRPA have been implicated in extracellular matrix-dependent signaling
  • having a potential role in adhesion-dependent signaling because it becomes inducibly tyrosyl-phosphorylated upon plating cells onto fibronectin, yet it fails to do so in response to growth factors
  • might serve as an adhesion-regulated signaling molecule
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to SHP-2, cSrc, concanavalin A (Con A)
  • cell & other
    REGULATION
    activated by phosphorylation cSrc
    inhibited by dephosphorylation SHP-2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    in schizophrenia brain tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS