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FLASH GENE

Symbol

MAPKAP1

contributors: mct/npt/pgu - updated : 13-02-2013

HGNC name	mitogen-activated protein kinase associated protein 1
HGNC id	18752

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Endocrine pancreas         Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a Raf-like Ras-binding domain (RBD) able to bind activated H-and K-Ras and a pleckstrin homology (PH) domain involved in lipid and membrane binding by MAPKAP1
	a nuclear localization signal
	two bipartite nuclear localization signals
	a peroxisomal targeting signal
	a PEST motif for rapid protein degradation
	C-terminus having the pleckstrin homology (PH) domain foldand omparison with known PH-domain structures suggests a putative binding site for phosphoinositides

HOMOLOGY

interspecies	homolog to murine Mapkap1 (97.1pc)
	homolog to rattus Mapkap1 (96.9pc)
	ortholog to S.cerevisiae Avo1

Homologene

FAMILY

SIN1 family

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus

basic FUNCTION	regulating MEKK2 dimerization and activation by forming a complex with inactive and non-phosphorylated MEKK2
	maintaining CRTC2 complex integrity and regulating Akt phosphorylation and substrates specificity
	may act as scaffold molecules in the regulation of signaling by JNK
	scaffold protein that organizes antiapoptotic responses in stressed cells
	plays an important role in the SAPK signaling pathway by binding to both ATF 2 and MAPK14
	may contribute to ATF2 signaling specificity by acting as a nuclear scaffold (Makino 2006)
	regulates B cell development
	mediates SGK1 protein interaction with CRTC2 protein complex and is required for selective activation of the epithelial sodium channel
	serves as a selectivity adaptor for the recruitment of CRTC2 targets
	plays key roles in the regulation of mitogen-activated protein kinase (MAPK) and MTOR signaling
	MAPKAP1 and CRTC2 are dispensable for the development and activation of T cells but play a role in natural T-regulatory (nTreg) cells differentiation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

ras pathway

a component

component of CRTC2, a protein kinase complex involved in AKT phosphorylation and cell signaling

INTERACTION

DNA

RNA

small molecule

protein	binding to MAPK
	binding to JNK
	interaction wth RICTOR (with Rictor are key components of mTORC2 and play an essential role in Akt phosphorylation and signaling)
	PCBP2, its binding partner, provides for the selective expression of cell survival factors through posttranslational events
	binds directly to both ATF2 and MAZPK14
	Ras-inhibitor
	MAPKAP1/CRTC2-AKT2 signaling axis is a key regulator of FOXO1 transcriptional activity in B cells
	serves as a selectivity adaptor for the recruitment of CRTC2 targets
	interacts with MAPKAP1, a component of the MTOR complex 2 (CRTC2), and this interaction is important both in the context of MTOR signaling
	specific domains of MTOR, RICTOR, or MAPKAP1 interacted with the internal domain (AA. 221-402) of NBN

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS